1ay2: Difference between revisions

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[[Image:1ay2.gif|left|200px]]
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[[Image:1ay2.png|left|200px]]


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{{STRUCTURE_1ay2|  PDB=1ay2  |  SCENE=  }}  
{{STRUCTURE_1ay2|  PDB=1ay2  |  SCENE=  }}  


'''STRUCTURE OF THE FIBER-FORMING PROTEIN PILIN AT 2.6 ANGSTROMS RESOLUTION'''
===STRUCTURE OF THE FIBER-FORMING PROTEIN PILIN AT 2.6 ANGSTROMS RESOLUTION===




==Overview==
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The crystallographic structure of Neisseria gonorrhoeae pilin, which assembles into the multifunctional pilus adhesion and virulence factor, reveals an alpha-beta roll fold with a striking 85 A alpha-helical spine and an O-linked disaccharide. Key residues stabilize interactions that allow sequence hypervariability, responsible for pilin's celebrated antigenic variation, within disulphide region beta-strands and connections. Pilin surface shape, hydrophobicity and sequence variation constrain pilus assembly to the packing of flat subunit faces against alpha 1 helices. Helical fibre assembly is postulated to form a core of coiled alpha 1 helices banded by beta-sheet, leaving carbohydrate and hypervariable sequence regions exposed to solvent.
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{{ABSTRACT_PUBMED_7477282}}


==About this Structure==
==About this Structure==
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[[Category: Saccharide]]
[[Category: Saccharide]]
[[Category: Type 4 pilin]]
[[Category: Type 4 pilin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:49:50 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:50:23 2008''

Revision as of 14:50, 30 June 2008

File:1ay2.png

Template:STRUCTURE 1ay2

STRUCTURE OF THE FIBER-FORMING PROTEIN PILIN AT 2.6 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 7477282

About this Structure

1AY2 is a Single protein structure of sequence from Neisseria gonorrhoeae. Full crystallographic information is available from OCA.

Reference

Structure of the fibre-forming protein pilin at 2.6 A resolution., Parge HE, Forest KT, Hickey MJ, Christensen DA, Getzoff ED, Tainer JA, Nature. 1995 Nov 2;378(6552):32-8. PMID:7477282

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