5grs: Difference between revisions

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<SX load='5grs' size='340' side='right' viewer='molstar' caption='[[5grs]], [[Resolution|resolution]] 5.40&Aring;' scene=''>
<SX load='5grs' size='340' side='right' viewer='molstar' caption='[[5grs]], [[Resolution|resolution]] 5.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5grs]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Fission_yeast Fission yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GRS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5GRS FirstGlance]. <br>
<table><tr><td colspan='2'>[[5grs]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GRS FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yhc|4yhc]], [[5gpd|5gpd]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.4&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">scp1, SPBC3B9.15c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284812 Fission yeast]), sre1, SPBC19C2.09 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284812 Fission yeast])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5grs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5grs OCA], [https://pdbe.org/5grs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5grs RCSB], [https://www.ebi.ac.uk/pdbsum/5grs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5grs ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5grs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5grs OCA], [http://pdbe.org/5grs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5grs RCSB], [http://www.ebi.ac.uk/pdbsum/5grs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5grs ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SCAP_SCHPO SCAP_SCHPO]] Escort protein required for sre1 processing at low sterol as well as oxygen levels. May regulate export of the scp1/sre1 complex from the ER at low sterol or oxygen levels. 4-methyl sterols bound to scp1 may mask an ER-export signal in scp1 leading to retention of the complex in the ER. Release of 4-methyl sterols may trigger a conformational change in the SSC domain of scp1 unmasking the ER export signal leading to recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of sre1 in the Golgi, release of the transcription factor fragment of sre1 from the membrane, its import into the nucleus and up-regulation of genes required for ergosterol biosynthesis as well as anaerobic growth.[UniProtKB:P97260]<ref>PMID:15797383</ref> <ref>PMID:17595166</ref> [[http://www.uniprot.org/uniprot/SREBP_SCHPO SREBP_SCHPO]] Transcriptional activator required for transcription of genes required for adaptation to anaerobic growth like those implicated in the nonrespiratory oxygen-consumptive biosynthetic pathways of sterol, heme, sphingolipid, and ubiquinone biosynthesis. May monitor oxygen levels through sterol synthesis steps which require oxygen.<ref>PMID:15797383</ref> <ref>PMID:16537923</ref> <ref>PMID:18276645</ref> 
[https://www.uniprot.org/uniprot/SCAP_SCHPO SCAP_SCHPO] Escort protein required for sre1 processing at low sterol as well as oxygen levels. May regulate export of the scp1/sre1 complex from the ER at low sterol or oxygen levels. 4-methyl sterols bound to scp1 may mask an ER-export signal in scp1 leading to retention of the complex in the ER. Release of 4-methyl sterols may trigger a conformational change in the SSC domain of scp1 unmasking the ER export signal leading to recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of sre1 in the Golgi, release of the transcription factor fragment of sre1 from the membrane, its import into the nucleus and up-regulation of genes required for ergosterol biosynthesis as well as anaerobic growth.[UniProtKB:P97260]<ref>PMID:15797383</ref> <ref>PMID:17595166</ref>  
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</SX>
</SX>
[[Category: Fission yeast]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Gong, X]]
[[Category: Schizosaccharomyces pombe 972h-]]
[[Category: Qian, H W]]
[[Category: Gong X]]
[[Category: Wu, J P]]
[[Category: Qian HW]]
[[Category: Yan, N]]
[[Category: Wu JP]]
[[Category: Protein complex]]
[[Category: Yan N]]
[[Category: Protein transport]]
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