5kuf: Difference between revisions

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<SX load='5kuf' size='340' side='right' viewer='molstar' caption='[[5kuf]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
<SX load='5kuf' size='340' side='right' viewer='molstar' caption='[[5kuf]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5kuf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KUF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5KUF FirstGlance]. <br>
<table><tr><td colspan='2'>[[5kuf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KUF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SYM:2S,4R-4-METHYLGLUTAMATE'>SYM</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kuh|5kuh]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SYM:2S,4R-4-METHYLGLUTAMATE'>SYM</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Grik2, Glur6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kuf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kuf OCA], [https://pdbe.org/5kuf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kuf RCSB], [https://www.ebi.ac.uk/pdbsum/5kuf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kuf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5kuf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kuf OCA], [http://pdbe.org/5kuf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kuf RCSB], [http://www.ebi.ac.uk/pdbsum/5kuf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kuf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GRIK2_RAT GRIK2_RAT]] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).<ref>PMID:17486098</ref> <ref>PMID:17115050</ref>
[https://www.uniprot.org/uniprot/GRIK2_RAT GRIK2_RAT] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).<ref>PMID:17486098</ref> <ref>PMID:17115050</ref>  
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</SX>
</SX>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chittori, S]]
[[Category: Rattus norvegicus]]
[[Category: Han, T H]]
[[Category: Chittori S]]
[[Category: Mayer, M L]]
[[Category: Han TH]]
[[Category: Merk, A]]
[[Category: Mayer ML]]
[[Category: Meyerson, J R]]
[[Category: Merk A]]
[[Category: Rao, P]]
[[Category: Meyerson JR]]
[[Category: Serpe, M]]
[[Category: Rao P]]
[[Category: Subramaniam, S]]
[[Category: Serpe M]]
[[Category: 4r-4-methylglutamate]]
[[Category: Subramaniam S]]
[[Category: Gluk2em with 2]]
[[Category: Signaling protein]]
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