5nl2: Difference between revisions
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<SX load='5nl2' size='340' side='right' viewer='molstar' caption='[[5nl2]], [[Resolution|resolution]] 6.60Å' scene=''> | <SX load='5nl2' size='340' side='right' viewer='molstar' caption='[[5nl2]], [[Resolution|resolution]] 6.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5nl2]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5nl2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NL2 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.6Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nl2 OCA], [https://pdbe.org/5nl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nl2 RCSB], [https://www.ebi.ac.uk/pdbsum/5nl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nl2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/ANO1_MOUSE ANO1_MOUSE] Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.<ref>PMID:18585372</ref> <ref>PMID:18724360</ref> <ref>PMID:21908539</ref> <ref>PMID:22002868</ref> <ref>PMID:22075693</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5nl2" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5nl2" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Anoctamin 3D structures|Anoctamin 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</SX> | </SX> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Brunner | [[Category: Brunner JD]] | ||
[[Category: Dutzler | [[Category: Dutzler R]] | ||
[[Category: Kalienkova | [[Category: Kalienkova V]] | ||
[[Category: Lam | [[Category: Lam KM]] | ||
[[Category: Neldner | [[Category: Neldner Y]] | ||
[[Category: Paulino | [[Category: Paulino C]] | ||
[[Category: Schenck | [[Category: Schenck S]] | ||
Latest revision as of 13:04, 15 November 2023
cryo-EM structure of the mTMEM16A ion channel at 6.6 A resolution.
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