1azv: Difference between revisions

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[[Image:1azv.~~gif~~|left|200px]]

[[Image:1azv.png|left|200px]]

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~~'''~~FAMILIAL ALS MUTANT G37R CUZNSOD (HUMAN)~~'''~~

===FAMILIAL ALS MUTANT G37R CUZNSOD (HUMAN)===

~~==Overview==~~

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The ~~X-ray crystal structure of a human copper/zinc superoxide dismutase mutant (G37R CuZnSOD) found in some patients with~~ the ~~inherited form of Lou Gehrig's disease (FALS) has been determined~~ to ~~1.9 angstroms resolution. The two SOD subunits have distinct environments in~~ the ~~crystal and are different in structure~~ at ~~their copper binding sites~~. ~~One subunit (subunit[intact]~~) ~~shows a four-coordinate ligand geometry of the copper ion~~, ~~whereas the other subunit (subunit[broken]) shows a three-coordinate geometry of~~ the ~~copper ion~~. ~~Also, subunit(intact) displays higher atomic displacement parameters for backbone atoms ((B) = 30 +/~~- ~~10 angstroms2) than subunit(broken) ((B) = 24 +/~~- 11 angstroms2). This structure is the first CuZnSOD to show large differences between the two subunits. Factors that may contribute to these differences are discussed and a possible link of a looser structure to FALS is suggested.

The line below this paragraph, {{ABSTRACT_PUBMED_9541385}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9541385 is the PubMed ID number.

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==Disease==

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[[Category: Oxidoreductase]]

[[Category: Superoxide acceptor]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 10~~:53:41 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:56:24 2008''

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-[[Image:1azv.gif|left|200px]]
+{{Seed}}
+[[Image:1azv.png|left|200px]]
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 {{STRUCTURE_1azv|  PDB=1azv  |  SCENE=  }}
-'''FAMILIAL ALS MUTANT G37R CUZNSOD (HUMAN)'''
+===FAMILIAL ALS MUTANT G37R CUZNSOD (HUMAN)===
-==Overview==
+<!--
-The X-ray crystal structure of a human copper/zinc superoxide dismutase mutant (G37R CuZnSOD) found in some patients with the inherited form of Lou Gehrig's disease (FALS) has been determined to 1.9 angstroms resolution. The two SOD subunits have distinct environments in the crystal and are different in structure at their copper binding sites. One subunit (subunit[intact]) shows a four-coordinate ligand geometry of the copper ion, whereas the other subunit (subunit[broken]) shows a three-coordinate geometry of the copper ion. Also, subunit(intact) displays higher atomic displacement parameters for backbone atoms ((B) = 30 +/- 10 angstroms2) than subunit(broken) ((B) = 24 +/- 11 angstroms2). This structure is the first CuZnSOD to show large differences between the two subunits. Factors that may contribute to these differences are discussed and a possible link of a looser structure to FALS is suggested.
+The line below this paragraph, {{ABSTRACT_PUBMED_9541385}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9541385 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9541385}}
 ==Disease==
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 [[Category: Oxidoreductase]]
 [[Category: Superoxide acceptor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:53:41 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:56:24 2008''