1azz: Difference between revisions

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[[Image:1azz.gif|left|200px]]
{{Seed}}
[[Image:1azz.png|left|200px]]


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{{STRUCTURE_1azz|  PDB=1azz  |  SCENE=  }}  
{{STRUCTURE_1azz|  PDB=1azz  |  SCENE=  }}  


'''FIDDLER CRAB COLLAGENASE COMPLEXED TO ECOTIN'''
===FIDDLER CRAB COLLAGENASE COMPLEXED TO ECOTIN===




==Overview==
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The crystal structure of fiddler crab collagenase complexed with the dimeric serine protease inhibitor ecotin at 2.5 A resolution reveals an extended cleft providing binding sites for at least 11 contiguous substrate residues. Comparison of the positions of nine intermolecular main chain hydrogen bonding interactions in the cleft, with the known sequences at the cleavage site of type I collagen, suggests that the protease binding loop of ecotin adopts a conformation mimicking that of the cleaved strand of collagen. A well-defined groove extending across the binding surface of the enzyme readily accommodates the two other polypeptide chains of the triple-helical substrate. These observations permit construction of a detailed molecular model for collagen recognition and cleavage by this invertebrate serine protease. Ecotin undergoes a pronounced internal structural rearrangement which permits binding in the observed conformation. The capacity for such rearrangement appears to be a key determinant of its ability to inhibit a wide range of serine proteases.
The line below this paragraph, {{ABSTRACT_PUBMED_9154920}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9154920 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9154920}}


==About this Structure==
==About this Structure==
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[[Category: Protease-substrate interaction]]
[[Category: Protease-substrate interaction]]
[[Category: Serine protease]]
[[Category: Serine protease]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:53:47 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:56:50 2008''

Revision as of 14:56, 30 June 2008

File:1azz.png

Template:STRUCTURE 1azz

FIDDLER CRAB COLLAGENASE COMPLEXED TO ECOTIN

Template:ABSTRACT PUBMED 9154920

About this Structure

1AZZ is a Protein complex structure of sequences from Celuca pugilator and Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix., Perona JJ, Tsu CA, Craik CS, Fletterick RJ, Biochemistry. 1997 May 6;36(18):5381-92. PMID:9154920

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