1b03: Difference between revisions

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[[Image:1b03.~~gif~~|left|200px]]

[[Image:1b03.png|left|200px]]

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~~'''~~SOLUTION STRUCTURE OF THE ANTIBODY-BOUND HIV-1IIIB V3 PEPTIDE~~'''~~

===SOLUTION STRUCTURE OF THE ANTIBODY-BOUND HIV-1IIIB V3 PEPTIDE===

~~==Overview==~~

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~~The refined solution structure of an 18~~-~~residue HIV~~-~~1IIIB V3 peptide in complex with the Fv fragment of an anti-gp120 antibody reveals an unexpected type VI beta-turn comprising residues RGPG at the center of a beta-hairpin.~~ The ~~central glycine and proline of~~ this ~~turn are linked by a cis peptide bond. The residues of~~ the ~~turn interact extensively with~~ the ~~antibody Fv~~. ~~15N[1H] NOE measurements show that the backbone of the peptide, including the central QRGPGR loop~~, is ~~well ordered in~~ the ~~complex~~. ~~The solution structure is significantly different from the X~~-~~ray structures of HIV~~-1MN V3 peptides bound to anti-peptide antibodies. These differences could be due to a two-residue (QR) insertion preceding the GPGR sequence in the HIV-1IIIB strain, and the much longer peptide epitope immobilized by the anti-gp120 antibody.

The line below this paragraph, {{ABSTRACT_PUBMED_10201400}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10201400 is the PubMed ID number.

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==About this Structure==

1B03 is a [[Single protein]] structure. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B03 OCA].

1B03 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B03 OCA].

==Reference==

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[[Category: Zvi, A.]]

[[Category: P1053 structure]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 10~~:54:06 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:57:15 2008''

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-[[Image:1b03.gif|left|200px]]
+{{Seed}}
+[[Image:1b03.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1b03|  PDB=1b03  |  SCENE=  }}
-'''SOLUTION STRUCTURE OF THE ANTIBODY-BOUND HIV-1IIIB V3 PEPTIDE'''
+===SOLUTION STRUCTURE OF THE ANTIBODY-BOUND HIV-1IIIB V3 PEPTIDE===
-==Overview==
+<!--
-The refined solution structure of an 18-residue HIV-1IIIB V3 peptide in complex with the Fv fragment of an anti-gp120 antibody reveals an unexpected type VI beta-turn comprising residues RGPG at the center of a beta-hairpin. The central glycine and proline of this turn are linked by a cis peptide bond. The residues of the turn interact extensively with the antibody Fv. 15N[1H] NOE measurements show that the backbone of the peptide, including the central QRGPGR loop, is well ordered in the complex. The solution structure is significantly different from the X-ray structures of HIV-1MN V3 peptides bound to anti-peptide antibodies. These differences could be due to a two-residue (QR) insertion preceding the GPGR sequence in the HIV-1IIIB strain, and the much longer peptide epitope immobilized by the anti-gp120 antibody.
+The line below this paragraph, {{ABSTRACT_PUBMED_10201400}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10201400 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10201400}}
 ==About this Structure==
-B03 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B03 OCA].
+B03 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B03 OCA].
 ==Reference==
@@ Line 26: / Line 30: @@
 [[Category: Zvi, A.]]
 [[Category: P1053 structure]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:54:06 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:57:15 2008''