6kg7: Difference between revisions

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<SX load='6kg7' size='340' side='right' viewer='molstar' caption='[[6kg7]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
<SX load='6kg7' size='340' side='right' viewer='molstar' caption='[[6kg7]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6kg7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KG7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KG7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6kg7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KG7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Piezo2, Fam38b ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6kg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kg7 OCA], [http://pdbe.org/6kg7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kg7 RCSB], [http://www.ebi.ac.uk/pdbsum/6kg7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kg7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kg7 OCA], [https://pdbe.org/6kg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kg7 RCSB], [https://www.ebi.ac.uk/pdbsum/6kg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kg7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PIEZ2_MOUSE PIEZ2_MOUSE]] Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents (PubMed:20813920, PubMed:24717433). Required for Merkel-cell mechanotransduction (PubMed:24717433). Plays a major role in light-touch mechanosensation (PubMed:25471886).<ref>PMID:20813920</ref> <ref>PMID:24717433</ref> <ref>PMID:25471886</ref>
[https://www.uniprot.org/uniprot/PIEZ2_MOUSE PIEZ2_MOUSE] Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents (PubMed:20813920, PubMed:24717433). Required for Merkel-cell mechanotransduction (PubMed:24717433). Plays a major role in light-touch mechanosensation (PubMed:25471886).<ref>PMID:20813920</ref> <ref>PMID:24717433</ref> <ref>PMID:25471886</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Deng, T]]
[[Category: Deng T]]
[[Category: Lei, J]]
[[Category: Lei J]]
[[Category: Li, X]]
[[Category: Li X]]
[[Category: Li, Y]]
[[Category: Li Y]]
[[Category: Liu, W]]
[[Category: Liu W]]
[[Category: Wang, L]]
[[Category: Wang L]]
[[Category: Xiao, B]]
[[Category: Xiao B]]
[[Category: Zhang, M]]
[[Category: Zhang M]]
[[Category: Zhao, Q]]
[[Category: Zhao Q]]
[[Category: Zhou, H]]
[[Category: Zhou H]]
[[Category: Mechanogating]]
[[Category: Mechanotransduction channel]]
[[Category: Membrane protein]]
[[Category: Piezo]]