6o96: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[6o96]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/ ], [~~http~~://en.wikipedia.org/wiki/~~African_clawed_frog African clawed frog~~] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O96 OCA]. For a guided tour on the structure components use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6O96 FirstGlance].

<table><tr><td colspan='2'>[[6o96]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O96 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=6O96 FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">hist1h2aj, LOC494591, XELAEV_18003602mg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog]), DOT1L, KIAA1814, KMT4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), UBB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=6o96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o96 OCA], [https://pdbe.org/6o96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o96 RCSB], [https://www.ebi.ac.uk/pdbsum/6o96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o96 ProSAT]</td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[~~http~~://proteopedia.org/fgij/fg.htm?mol=6o96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o96 OCA], [~~http~~://pdbe.org/6o96 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6o96 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6o96 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6o96 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN]] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. [[http://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H32_XENLA H32_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

[https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

== Publication Abstract from PubMed ==

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__TOC__

</SX>

[[Category: ~~African clawed frog]]~~

[[Category: Homo sapiens]]

~~[[Category: Histone-lysine N-methyltransferase]]~~

~~[[Category: Human~~]]

[[Category: Large Structures]]

[[Category: Armache, J P]]

[[Category: Synthetic construct]]

[[Category: Armache, K J]]

[[Category: Xenopus laevis]]

[[Category: Chen, R]]

[[Category: Armache J-P]]

[[Category: Ioannes~~, P E.De~~]]

[[Category: Armache K-J]]

[[Category: Miao, W]]

[[Category: Chen R]]

[[Category: Nudler, E]]

[[Category: De Ioannes PE]]

[[Category: Valencia-Sanchez~~, M I~~]]

[[Category: Miao W]]

[[Category: Vasilyev, N]]

[[Category: Nudler E]]

~~[[Category: Chromatin modifier]]~~

[[Category: Valencia-Sanchez MI]]

~~[[Category: Complex]]~~

[[Category: Vasilyev N]]

~~[[Category: Structural protein]]~~

~~[[Category: Structural protein-dna-transferase complex]]~~

~~[[Category: Transferase~~]]

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@@ Line 3: / Line 3: @@
 <SX load='6o96' size='340' side='right' viewer='molstar' caption='[[6o96]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6o96]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/ ], [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O96 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6O96 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6o96]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O96 FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hist1h2aj, LOC494591, XELAEV_18003602mg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog]), DOT1L, KIAA1814, KMT4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), UBB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o96 OCA], [https://pdbe.org/6o96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o96 RCSB], [https://www.ebi.ac.uk/pdbsum/6o96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o96 ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6o96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o96 OCA], [http://pdbe.org/6o96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o96 RCSB], [http://www.ebi.ac.uk/pdbsum/6o96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o96 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN]] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. [[http://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H32_XENLA H32_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
+[https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 28: / Line 26: @@
 __TOC__
 </SX>
-[[Category: African clawed frog]]
+[[Category: Homo sapiens]]
-[[Category: Histone-lysine N-methyltransferase]]
-[[Category: Human]]
 [[Category: Large Structures]]
-[[Category: Armache, J P]]
+[[Category: Synthetic construct]]
-[[Category: Armache, K J]]
+[[Category: Xenopus laevis]]
-[[Category: Chen, R]]
+[[Category: Armache J-P]]
-[[Category: Ioannes, P E.De]]
+[[Category: Armache K-J]]
-[[Category: Miao, W]]
+[[Category: Chen R]]
-[[Category: Nudler, E]]
+[[Category: De Ioannes PE]]
-[[Category: Valencia-Sanchez, M I]]
+[[Category: Miao W]]
-[[Category: Vasilyev, N]]
+[[Category: Nudler E]]
-[[Category: Chromatin modifier]]
+[[Category: Valencia-Sanchez MI]]
-[[Category: Complex]]
+[[Category: Vasilyev N]]
-[[Category: Structural protein]]
-[[Category: Structural protein-dna-transferase complex]]
-[[Category: Transferase]]