1b0z: Difference between revisions

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[[Image:1b0z.gif|left|200px]]
{{Seed}}
[[Image:1b0z.png|left|200px]]


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{{STRUCTURE_1b0z|  PDB=1b0z  |  SCENE=  }}  
{{STRUCTURE_1b0z|  PDB=1b0z  |  SCENE=  }}  


'''The crystal structure of phosphoglucose isomerase-an enzyme with autocrine motility factor activity in tumor cells'''
===The crystal structure of phosphoglucose isomerase-an enzyme with autocrine motility factor activity in tumor cells===




==Overview==
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Phosphoglucose isomerase catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate. In addition, phosphoglucose isomerase has been shown to have functions equivalent to neuroleukin, autocrine motility factor, and maturation factor. Here we present the crystal structures of phosphoglucose isomerase complexed with 5-phospho-D-arabinonate and N-bromoacetylethanolamine phosphate at 2.5- and 2.3-A resolution, respectively. The inhibitors bind to a region within the domains' interface and interact with a histidine residue (His(306)) from the other subunit. We also demonstrated that the inhibitors not only affect the enzymatic activity of phosphoglucose isomerase, but can also inhibit the autocrine motility factor-induced cell motility of CT-26 mouse colon tumor cells. These results indicate that the substrate and the receptor binding sites of phosphoglucose isomerase and autocrine motility factor are located within close proximity to each other. Based on these two complex structures, together with biological and biochemical results, we propose a possible isomerization mechanism for phosphoglucose isomerase.
The line below this paragraph, {{ABSTRACT_PUBMED_10770936}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10770936 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10770936}}


==About this Structure==
==About this Structure==
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[[Category: Neuroleukin]]
[[Category: Neuroleukin]]
[[Category: Phosphoglucose isomerase]]
[[Category: Phosphoglucose isomerase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:56:18 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:00:50 2008''

Revision as of 15:00, 30 June 2008

File:1b0z.png

Template:STRUCTURE 1b0z

The crystal structure of phosphoglucose isomerase-an enzyme with autocrine motility factor activity in tumor cells

Template:ABSTRACT PUBMED 10770936

About this Structure

1B0Z is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

The crystal structure of phosphoglucose isomerase/autocrine motility factor/neuroleukin complexed with its carbohydrate phosphate inhibitors suggests its substrate/receptor recognition., Chou CC, Sun YJ, Meng M, Hsiao CD, J Biol Chem. 2000 Jul 28;275(30):23154-60. PMID:10770936

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