Sandbox Reserved 895: Difference between revisions
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RPE65 is located within the hRPE cells located in the back of the eye. The human retinal pigment epithelium is responsible for regulating the nourishment of the retina. Since the retinoid (visual) cycle requires the incorporation of light into catalyzing chemical reactions, hRPE cells are light sensitive. | RPE65 is located within the hRPE cells located in the back of the eye. The human retinal pigment epithelium is responsible for regulating the nourishment of the retina. Since the retinoid (visual) cycle requires the incorporation of light into catalyzing chemical reactions, hRPE cells are light sensitive. | ||
== '''The Retinoid (Visual) Cycle ''' == | |||
For humans to see, the retinoid (visual) cycle converts incident light entering into the eye to electrochemical signals that can be transmitted to the brain as neuronal impulses. The chemical reactions that take place within the retinoid cycle allows the regeneration of key intermediates to allow for vision to take place. Dysregulation of these chemical processes, associated with disease, can lead to alterations in vision and blindness. Age related macular degeneration is an example of the dysregulation within the retinoid cycle. The 3-dimensional binding site of bovine RPE65 to an exogenous substrate (''R'')-emixustat shown in '''Figure 1''', was a tested drug treatment for dry age related macular degeneration. | |||
= References = | = References = | ||
<references/> | <references/> | ||
