Sandbox Reserved 1606: Difference between revisions
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==Background== | ==Background== | ||
The [https://en.wikipedia.org/wiki/ABCG2 ABCG2 multidrug transporter] is a membrane protein from the '''A'''TP-'''B'''inding '''C'''assette [https://en.wikipedia.org/wiki/ATP-binding_cassette_transporter (ABC)] transporter family, specifically the G-subfamily. Also | The [https://en.wikipedia.org/wiki/ABCG2 ABCG2 multidrug transporter] is a membrane protein from the '''A'''TP-'''B'''inding '''C'''assette [https://en.wikipedia.org/wiki/ATP-binding_cassette_transporter (ABC)] transporter family, specifically the G-subfamily. Also known as the breast cancer resistance protein (BCRP), ABCG2 has physiological roles in various tissue cells including the [https://en.wikipedia.org/wiki/Mammary_gland mammary gland] and the [https://en.wikipedia.org/wiki/Blood%E2%80%93brain_barrier blood-brain], [https://en.wikipedia.org/wiki/Blood%E2%80%93testis_barrier blood-testis], and [https://en.wikipedia.org/wiki/Placenta maternal-fetal] barriers.<ref name="Taylor"/> ABCG2 protects cells by exporting [https://en.wikipedia.org/wiki/Xenobiotic xenobiotic] molecules out of the cell using ATP hydrolysis. ABCG2 also affects the [https://en.wikipedia.org/wiki/Pharmacokinetics pharmacokinetics] of many drugs and contributes to [https://en.wikipedia.org/wiki/Multiple_drug_resistance multidrug resistance].<ref name="Manolaridis"/> | ||
== Structural highlights == | == Structural highlights == | ||
