Sandbox Reserved 1619: Difference between revisions
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===Background=== | ===Background=== | ||
Gamma Secretase (GS) is a transmembrane [https://en.wikipedia.org/wiki/Aspartic_protease aspartatic protease]. It catalyzes peptide bond hydrolysis of type I integral membrane proteins such as Notch, amyloid precursor protein (APP), and various other substrates. It recognizes and catalyzes the reaction with its substrate using 3 residue segments. These substrates generate amyloid-β (Aβ). This product is important for various neural processes, and it is well known for its | Gamma Secretase (GS) is a transmembrane [https://en.wikipedia.org/wiki/Aspartic_protease aspartatic protease]. It catalyzes peptide bond hydrolysis of type I integral membrane proteins such as Notch, amyloid precursor protein (APP), and various other substrates. It recognizes and catalyzes the reaction with its substrate using 3 residue segments. These substrates generate amyloid-β (Aβ). This product is important for various neural processes, and it is well known for its implications with [https://en.wikipedia.org/wiki/Alzheimer%27s_disease Alzheimer's disease (AD).] This has made GS a popular drug target, specifically using gamma secretase inhibitors. However, due to the nature of the enzyme having various neural functions, there are dangerous side effects when it is inhibited. | ||
===Overall Structure=== | ===Overall Structure=== | ||
