Huntingtin: Difference between revisions

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HTT is mostly cytoplasmic. However, it can be aslo observed in the nucleus, as HTT comprises nuclear localization sequence in its NH2 terminus <ref>DOI 10.1074/jbc.M112.412379</ref>. Its nuclear localization implies for its role in transcription regulation. There are many transcription factors that were decribed to interact with mHTT. However, less known are the interactions with wild-type HTT. An example of a well described target gene of HTT-mediated transcription regulation is the brain derived nerve growth factor (BDNF) <ref>DOI 10.1038/ng1219</ref>.
HTT is mostly cytoplasmic. However, it can be aslo observed in the nucleus, as HTT comprises nuclear localization sequence in its NH2 terminus <ref>DOI 10.1074/jbc.M112.412379</ref>. Its nuclear localization implies for its role in transcription regulation. An example of a well described target gene of HTT-mediated transcription regulation is the brain derived nerve growth factor (BDNF) <ref>DOI 10.1038/ng1219</ref>. However, there are more transcription factors described to interact with mHTT, as their interaction may lead to transcription dysregulation. Thanks to its abnormal structure, mHTT supresses the expression of PGC1-α — a transcription factor responsible for the regulation of many mitochondrial genes <ref>DOI 10.1007/s11062-013-9341-1</ref>.




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