Sandbox Reserved 1627: Difference between revisions

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==Structural Overview==

The insulin receptor is a [http://en.wikipedia.org/wiki/Dimer_(chemistry) dimer] of heterodimers made of two <scene name='83/832953/Alpha_subunits/4'>alpha subunits</scene> and two <scene name='83/832953/Beta_subunits/3'>beta subunits</scene> <ref name="Tatulian">PMID:26322622</ref>. Within the extracellular ectodomain, there are four potential <scene name='83/832953/Binding_sites/3'>binding sites</scene> that can interact with insulin ligands on the extracellular side of the membrane. The insulin receptor has only been imaged in pieces, which has led to proposed structures (see [http://www.rcsb.org/structure/1IR3 PDB 1IR3]) of the entirety of the receptor based on the function of downstream tyrosine [http://en.wikipedia.org/wiki/Autophosphorylation autophosphorylation]. <ref name= "Hubbard"> DOI: 10.1093/emboj/16.18.5572 </ref>

The insulin receptor is a [http://en.wikipedia.org/wiki/Dimer_(chemistry) dimer] of heterodimers made of two <scene name='83/832953/Alpha_subunits/4'>alpha subunits</scene> and two <scene name='83/832953/Beta_subunits/4'>beta subunits</scene> <ref name="Tatulian">PMID:26322622</ref>. Within the extracellular ectodomain, there are four potential <scene name='83/832953/Binding_sites/3'>binding sites</scene> that can interact with insulin ligands on the extracellular side of the membrane. The insulin receptor has only been imaged in pieces, which has led to proposed structures (see [http://www.rcsb.org/structure/1IR3 PDB 1IR3]) of the entirety of the receptor based on the function of downstream tyrosine [http://en.wikipedia.org/wiki/Autophosphorylation autophosphorylation]. <ref name= "Hubbard"> DOI: 10.1093/emboj/16.18.5572 </ref>

====Alpha Subunits====

Sandbox Reserved 1627: Difference between revisions

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@@ Line 7: / Line 7: @@
 ==Structural Overview==
-The insulin receptor is a [http://en.wikipedia.org/wiki/Dimer_(chemistry) dimer] of heterodimers made of two <scene name='83/832953/Alpha_subunits/4'>alpha subunits</scene> and two <scene name='83/832953/Beta_subunits/3'>beta subunits</scene> <ref name="Tatulian">PMID:26322622</ref>. Within the extracellular ectodomain, there are four potential <scene name='83/832953/Binding_sites/3'>binding sites</scene> that can interact with insulin ligands on the extracellular side of the membrane. The insulin receptor has only been imaged in pieces, which has led to proposed structures (see [http://www.rcsb.org/structure/1IR3 PDB 1IR3]) of the entirety of the receptor based on the function of downstream tyrosine [http://en.wikipedia.org/wiki/Autophosphorylation autophosphorylation]. <ref name= "Hubbard"> DOI: 10.1093/emboj/16.18.5572 </ref>
+The insulin receptor is a [http://en.wikipedia.org/wiki/Dimer_(chemistry) dimer] of heterodimers made of two <scene name='83/832953/Alpha_subunits/4'>alpha subunits</scene> and two <scene name='83/832953/Beta_subunits/4'>beta subunits</scene> <ref name="Tatulian">PMID:26322622</ref>. Within the extracellular ectodomain, there are four potential <scene name='83/832953/Binding_sites/3'>binding sites</scene> that can interact with insulin ligands on the extracellular side of the membrane. The insulin receptor has only been imaged in pieces, which has led to proposed structures (see [http://www.rcsb.org/structure/1IR3 PDB 1IR3]) of the entirety of the receptor based on the function of downstream tyrosine [http://en.wikipedia.org/wiki/Autophosphorylation autophosphorylation]. <ref name= "Hubbard"> DOI: 10.1093/emboj/16.18.5572 </ref>
 ====Alpha Subunits====