Sandbox Reserved 1613: Difference between revisions
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==Introduction== | ==Introduction== | ||
The ABCG2 transporter protein is a notable transmembrane protein. It transports xenobiotic material out of cells in many tissues. ABCG2 belongs to the family of 48 transporter proteins called ATP-binding cassette transporters (ABC transporters). The ABC transporters differ from each other by their size structure, and ordering of domains. Ample evidence has shown a link between multi-drug resistance and the presence of ABC transporters in the plasma membrane of cells. This is important as multi-drug resistance is one of the major indicators of bad prognoses in cancer treatment. In fact, 19 of the 48 transporters of the ABC family have been shown to transport chemotherapeutic agents out of cells. In recent studies, the unique two binding cavity structure, inwardly facing nucleotide binding domain and condensed EL-3 structure of ABCG2 have been elucidated, among other features. These new discoveries have allowed for progress towards discovering the exact link between cancer and the ABC transporter family and have allowed for more effective drug treatment of cancer. | The ABCG2 transporter protein is a notable transmembrane protein. It transports xenobiotic material out of cells in many tissues. ABCG2 belongs to the family of 48 transporter proteins called ATP-binding cassette transporters (ABC transporters). The ABC transporters differ from each other by their size structure, and ordering of domains. Ample evidence has shown a link between multi-drug resistance and the presence of ABC transporters in the plasma membrane of cells. This is important as multi-drug resistance is one of the major indicators of bad prognoses in cancer treatment. In fact, 19 of the 48 transporters of the ABC family have been shown to transport chemotherapeutic agents out of cells. In recent studies, the unique two binding cavity structure, inwardly facing nucleotide binding domain and condensed EL-3 structure of ABCG2 have been elucidated, among other features. These new discoveries have allowed for progress towards discovering the exact link between cancer and the ABC transporter family and have allowed for more effective drug treatment of cancer. | ||
==The ABC Familial Links== | ==The ABC Familial Links== | ||
