Sandbox Reserved 1613: Difference between revisions

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==Introduction==

The ABCG2 transporter protein is a notable [https://en.wikipedia.org/wiki/Transmembrane_protein transmembrane protein]. It transports [https://en.wikipedia.org/wiki/Xenobiotic xenobiotic] material out of cells in many tissues. ABCG2 belongs to the family of 48 transporter proteins called ATP-binding cassette transporters (ABC transporters). The ABC transporters differ from each other by their size structure, and ordering of domains. Ample evidence has shown a link between [https://en.wikipedia.org/wiki/Multiple_drug_resistance multi-drug resistance] and the presence of ABC transporters in the plasma membrane of cells. This is important as multi-drug resistance is one of the major indicators of bad prognoses in cancer treatment. In fact, 19 of the 48 transporters of the ABC family have been shown to transport [https://en.wikipedia.org/wiki/List_of_chemotherapeutic_agents chemotherapeutic agents] out of cells<ref name="Robey"/>. In recent studies, with [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryogenic electronic microscopy] (Cryo EM), the unique <scene name='83/832939/2_cavities/1'>two cavity substrate transport structure</scene>, inward facing nucleotide binding domain and <scene name='83/832939/El-3/3'>condensed EL-3 structure</scene> of ABCG2 have been elucidated, among other features. These new discoveries have allowed for progress towards discovering the exact link between cancer and the ABC transporter family and have allowed for more effective drug treatment of cancer. This page will focus on the family of ABC transporters before delving into unique structural features of ABCG2 and finally describing the effects of this transporter on anti-cancer treatment.

The ABCG2 transporter protein is a notable [https://en.wikipedia.org/wiki/Transmembrane_protein transmembrane protein]. It transports [https://en.wikipedia.org/wiki/Xenobiotic xenobiotic] material out of cells in many tissues. ABCG2 belongs to the family of 48 transporter proteins called ATP-binding cassette transporters (ABC transporters). The ABC transporters differ from each other by their size structure, and ordering of domains. Ample evidence has shown a link between [https://en.wikipedia.org/wiki/Multiple_drug_resistance multi-drug resistance] and the presence of ABC transporters in the plasma membrane of cells. This is important as multi-drug resistance is one of the major indicators of bad prognoses in cancer treatment. In fact, 19 of the 48 transporters of the ABC family have been shown to transport [https://en.wikipedia.org/wiki/List_of_chemotherapeutic_agents chemotherapeutic agents] out of cells<ref name="Robey">PMID:29643473</ref>. In recent studies, with [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryogenic electronic microscopy] (Cryo EM), the unique <scene name='83/832939/2_cavities/1'>two cavity substrate transport structure</scene>, inward facing nucleotide binding domain and <scene name='83/832939/El-3/3'>condensed EL-3 structure</scene> of ABCG2 have been elucidated, among other features. These new discoveries have allowed for progress towards discovering the exact link between cancer and the ABC transporter family and have allowed for more effective drug treatment of cancer. This page will focus on the family of ABC transporters before delving into unique structural features of ABCG2 and finally describing the effects of this transporter on anti-cancer treatment.

==ABC Transporter Family==

Sandbox Reserved 1613: Difference between revisions

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 <StructureSection load='6ffc' size='350' frame='true' side='right' caption='Figure 1: ABCG2 6FFC' scene=’’>
 ==Introduction==
-The ABCG2 transporter protein is a notable [https://en.wikipedia.org/wiki/Transmembrane_protein transmembrane protein]. It transports [https://en.wikipedia.org/wiki/Xenobiotic xenobiotic] material out of cells in many tissues. ABCG2 belongs to the family of 48 transporter proteins called ATP-binding cassette transporters (ABC transporters). The ABC transporters differ from each other by their size structure, and ordering of domains. Ample evidence has shown a link between [https://en.wikipedia.org/wiki/Multiple_drug_resistance multi-drug resistance] and the presence of ABC transporters in the plasma membrane of cells. This is important as multi-drug resistance is one of the major indicators of bad prognoses in cancer treatment. In fact, 19 of the 48 transporters of the ABC family have been shown to transport [https://en.wikipedia.org/wiki/List_of_chemotherapeutic_agents chemotherapeutic agents] out of cells<ref name="Robey"/>. In recent studies, with [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryogenic electronic microscopy] (Cryo EM), the unique <scene name='83/832939/2_cavities/1'>two cavity substrate transport structure</scene>, inward facing nucleotide binding domain and <scene name='83/832939/El-3/3'>condensed EL-3 structure</scene> of ABCG2 have been elucidated, among other features. These new discoveries have allowed for progress towards discovering the exact link between cancer and the ABC transporter family and have allowed for more effective drug treatment of cancer. This page will focus on the family of ABC transporters before delving into unique structural features of ABCG2 and finally describing the effects of this transporter on anti-cancer treatment.
+The ABCG2 transporter protein is a notable [https://en.wikipedia.org/wiki/Transmembrane_protein transmembrane protein]. It transports [https://en.wikipedia.org/wiki/Xenobiotic xenobiotic] material out of cells in many tissues. ABCG2 belongs to the family of 48 transporter proteins called ATP-binding cassette transporters (ABC transporters). The ABC transporters differ from each other by their size structure, and ordering of domains. Ample evidence has shown a link between [https://en.wikipedia.org/wiki/Multiple_drug_resistance multi-drug resistance] and the presence of ABC transporters in the plasma membrane of cells. This is important as multi-drug resistance is one of the major indicators of bad prognoses in cancer treatment. In fact, 19 of the 48 transporters of the ABC family have been shown to transport [https://en.wikipedia.org/wiki/List_of_chemotherapeutic_agents chemotherapeutic agents] out of cells<ref name="Robey">PMID:29643473</ref>. In recent studies, with [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryogenic electronic microscopy] (Cryo EM), the unique <scene name='83/832939/2_cavities/1'>two cavity substrate transport structure</scene>, inward facing nucleotide binding domain and <scene name='83/832939/El-3/3'>condensed EL-3 structure</scene> of ABCG2 have been elucidated, among other features. These new discoveries have allowed for progress towards discovering the exact link between cancer and the ABC transporter family and have allowed for more effective drug treatment of cancer. This page will focus on the family of ABC transporters before delving into unique structural features of ABCG2 and finally describing the effects of this transporter on anti-cancer treatment.
 ==ABC Transporter Family==