Sandbox Reserved 1600: Difference between revisions
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Oxygen toxicity is a fatal problem among all organisms, but can easily occur in prokaryotes due to their low oxygen tolerance. In prokaryotes, the [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171616/ cytochrome bd oxygen reductases] function to quickly reduce the concentration of O₂ into H₂O to protect the cell from detrimental effects. Without proper functioning of these enzymes, or if O₂ concentrations are too high, the concentrations of the intermediates formed from the reduction reaction will increase and can be detrimental. As a result, cytochrome bd oxidases facilitate growth in both pathogenic and commensal bacteria causing them to be a vital enzyme for cellular growth and division. Their importance in anaerobic prokaryotes makes bd oxidases useful targets for drug development to combat bacterial [https://en.wikipedia.org/wiki/Infection#Bacterial_or_viral infection].<ref name=”Borisov”>PMID:21756872</ref> | Oxygen toxicity is a fatal problem among all organisms, but can easily occur in prokaryotes due to their low oxygen tolerance. In prokaryotes, the [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171616/ cytochrome bd oxygen reductases] function to quickly reduce the concentration of O₂ into H₂O to protect the cell from detrimental effects. Without proper functioning of these enzymes, or if O₂ concentrations are too high, the concentrations of the intermediates formed from the reduction reaction will increase and can be detrimental. As a result, cytochrome bd oxidases facilitate growth in both pathogenic and commensal bacteria causing them to be a vital enzyme for cellular growth and division. Their importance in anaerobic prokaryotes makes bd oxidases useful targets for drug development to combat bacterial [https://en.wikipedia.org/wiki/Infection#Bacterial_or_viral infection].<ref name=”Borisov”>PMID:21756872</ref> | ||
= References = | |||
<references/> | <references/> | ||
=Proteopedia Resources= | |||
* [http://proteopedia.org/wiki/index.php/5doq Structure of bd oxidase from Geobacillus thermodenitrificans] | * [http://proteopedia.org/wiki/index.php/5doq Structure of bd oxidase from Geobacillus thermodenitrificans] | ||
* [http://proteopedia.org/wiki/index.php/6rko Cryo-EM structure of the E. coli cytochrome bd-I oxidase] | * [http://proteopedia.org/wiki/index.php/6rko Cryo-EM structure of the E. coli cytochrome bd-I oxidase] | ||
