5e26: Difference between revisions

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<StructureSection load='5e26' size='340' side='right'caption='[[5e26]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
<StructureSection load='5e26' size='340' side='right'caption='[[5e26]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5e26]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E26 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5E26 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5e26]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E26 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PAU:PANTOTHENOIC+ACID'>PAU</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PANK2, C20orf48 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PAU:PANTOTHENOIC+ACID'>PAU</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e26 OCA], [https://pdbe.org/5e26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e26 RCSB], [https://www.ebi.ac.uk/pdbsum/5e26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e26 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5e26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e26 OCA], [http://pdbe.org/5e26 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e26 RCSB], [http://www.ebi.ac.uk/pdbsum/5e26 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e26 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/PANK2_HUMAN PANK2_HUMAN]] Atypical pantothenate kinase-associated neurodegeneration;Classic pantothenate kinase-associated neurodegeneration. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/PANK2_HUMAN PANK2_HUMAN] Atypical pantothenate kinase-associated neurodegeneration;Classic pantothenate kinase-associated neurodegeneration. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PANK2_HUMAN PANK2_HUMAN]] May be the master regulator of the CoA biosynthesis.  
[https://www.uniprot.org/uniprot/PANK2_HUMAN PANK2_HUMAN] May be the master regulator of the CoA biosynthesis.


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Pantothenate kinase]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C H]]
[[Category: BROWN PJ]]
[[Category: BROWN, P J]]
[[Category: Bountra C]]
[[Category: Bountra, C]]
[[Category: CHENG C]]
[[Category: CHENG, C]]
[[Category: DONG A]]
[[Category: DONG, A]]
[[Category: Edwards AM]]
[[Category: Edwards, A M]]
[[Category: HONG BS]]
[[Category: HONG, B S]]
[[Category: HUTCHINSON A]]
[[Category: HUTCHINSON, A]]
[[Category: LOPPNAU P]]
[[Category: LOPPNAU, P]]
[[Category: RAVICHANDRAN M]]
[[Category: RAVICHANDRAN, M]]
[[Category: SEITOVA A]]
[[Category: SEITOVA, A]]
[[Category: TEMPEL W]]
[[Category: Structural genomic]]
[[Category: TEMPEL, W]]
[[Category: Pank2]]
[[Category: Sgc]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/5e26"