5ede: Difference between revisions

<table><tr><td colspan='2'>[[5ede]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EDE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EDE FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5M6:1-(4-CHLOROPHENYL)-3-METHYL-~{N}-[[(2~{R})-OXOLAN-2-YL]METHYL]THIENO[2,3-C]PYRAZOLE-5-CARBOXAMIDE'>5M6</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ede FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ede OCA], [https://pdbe.org/5ede PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ede RCSB], [https://www.ebi.ac.uk/pdbsum/5ede PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ede ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>  

[[Category: Homo sapiens]]

[[Category: Joseph C]]

[[Category: Rudolph MG]]