1b4y: Difference between revisions

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[[Image:1b4y.gif|left|200px]]
{{Seed}}
[[Image:1b4y.png|left|200px]]


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{{STRUCTURE_1b4y|  PDB=1b4y  |  SCENE=  }}  
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'''STRUCTURE AND MECHANISM OF FORMATION OF THE H-Y5 ISOMER OF AN INTRAMOLECULAR DNA TRIPLE HELIX.'''
===STRUCTURE AND MECHANISM OF FORMATION OF THE H-Y5 ISOMER OF AN INTRAMOLECULAR DNA TRIPLE HELIX.===




==Overview==
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H-DNA, thought to play a regulatory role in transcription, exists in two isomeric forms, H-y3 and H-y5. We present the first solution structure of a DNA fragment representing the H-y5 fold. The structure shows the H-y5 triple helix, and for the first time how in an H-DNA isomer the purine strand extension interacts with the triplex loop. It gives direct insight into the mechanism of H-DNA formation, and explains a host of biochemical and biophysical data on the relative stability of the H-DNA isomers. In addition, the observed interaction of the purine strand extension and the triplex loop provides new clues to the design of clamp-type triple helix-forming oligonucleotides.
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{{ABSTRACT_PUBMED_10467098}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B4Y OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B4Y OCA].  


==Reference==
==Reference==
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[[Category: H-dna]]
[[Category: H-dna]]
[[Category: Triple helix]]
[[Category: Triple helix]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:04:43 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:16:30 2008''

Revision as of 15:16, 30 June 2008

File:1b4y.png

Template:STRUCTURE 1b4y

STRUCTURE AND MECHANISM OF FORMATION OF THE H-Y5 ISOMER OF AN INTRAMOLECULAR DNA TRIPLE HELIX.

Template:ABSTRACT PUBMED 10467098

About this Structure

Full experimental information is available from OCA.

Reference

Structure and mechanism of formation of the H-y5 isomer of an intramolecular DNA triple helix., van Dongen MJ, Doreleijers JF, van der Marel GA, van Boom JH, Hilbers CW, Wijmenga SS, Nat Struct Biol. 1999 Sep;6(9):854-9. PMID:10467098

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