Amino acid composition: Difference between revisions
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The ''amino acid composition'' of a protein refers to the percentages of each amino acid in the sequence of that protein. The percentage, sometimes called the Mole percentage, is calculated as the number of a given amino acid divided by the total number of amino acids in the protein chain or molecule. | The ''amino acid composition'' of a protein refers to the percentages of each amino acid in the sequence of that protein. The percentage, sometimes called the Mole percentage, is calculated as the number of a given amino acid divided by the total number of amino acids in the protein chain or molecule. | ||
The strongest predictor of amino acid composition is the GC-content of the organism's genome<ref name="tekala-genomes">PMID: 12384285</ref>. Other, weaker influences are | The strongest predictor of amino acid composition is the GC-content of the organism's genome<ref name="tekala-genomes">PMID: 12384285</ref>. Other, weaker influences are: | ||
*'''Growth temperatures''' (mesophily/thermophily/hyperthermophily). Thermophiles have more glutamic acid (with reduction in glutamine), and more lysine and arginine<ref name="tekala-genomes" />. This likely relates to the larger number of [[salt bridges]] in proteins of thermophiles, believe to contribute to thermostability. | |||
Thermophiles have more glutamic acid (with reduction in glutamine), and more lysine and arginine <ref name="tekala-genomes" />. This likely relates to the larger number of [[salt bridges]] in proteins of thermophiles, believe to contribute to thermostability. | *'''Chain length'''. | ||
Proteins of thermophiles are, on average, shorter than those of mesophiles. Average lengths are 283 and 340, respectively<ref name="tekala-genomes" />. | |||
==References== | ==References== | ||
<references /> | <references /> | ||
