Amino acid composition: Difference between revisions
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Other, weaker influences are: | Other, weaker influences are: | ||
*'''Growth temperatures''' (mesophily/thermophily/hyperthermophily). Thermophiles have more glutamic acid (with reduction in glutamine), and more lysine and arginine<ref name="tekala-genomes" />. This likely relates to the larger number of [[salt bridges]] in proteins of thermophiles, believe to contribute to thermostability. | *'''Growth temperatures''' (mesophily/thermophily/hyperthermophily). Thermophiles have more glutamic acid (with reduction in glutamine), and more lysine and arginine<ref name="tekala-genomes" />. This likely relates to the larger number of [[salt bridges]] in proteins of thermophiles, believe to contribute to thermostability. | ||
*'''Chain length'''. | *'''Chain length'''. Proteins of thermophiles are, on average, shorter than those of mesophiles. Average lengths are 283 and 340, respectively<ref name="tekala-genomes" />. A study of ~550,000 proteins with lengths 50-200 amino acids<ref name="length">PMID:18780815</ref> concluded: | ||
Proteins of thermophiles are, on average, shorter than those of mesophiles. Average lengths are 283 and 340, respectively<ref name="tekala-genomes" />. | **Increased with length, reaching a plateau: Ala, Asp, Glu, Gly, Pro, Val. | ||
**Decreased with length: Cys, Phe, His, Ile, Lys, Met, Asn, Ser. | |||
**Leu and Tyr are highest in short and long chains, and less frequent in middle-sized proteins. | |||
**Arg peaks in middle-sized proteins. | |||
==References== | ==References== | ||
<references /> | <references /> | ||
