Sandbox Reserved 896: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 18: | Line 18: | ||
BD1 Structure | BD1 Structure | ||
BD1 contains a left-handed alpha-helical bundle formed by four alpha helices: aZ, aA, aB, and aC. | BD1 contains a left-handed alpha-helical bundle formed by four alpha helices: aZ, aA, aB, and aC. | ||
It's structure is similar to bromodomains of p300/CBP-associated factor (PCAF), GCN5, and double bromodomain module of TAF1. | It's structure is similar to bromodomains of p300/CBP-associated factor (PCAF), GCN5, and double bromodomain module of TAF1. | ||
| Line 24: | Line 25: | ||
BD1 vs. BD2 Drug Selectivity | BD1 vs. BD2 Drug Selectivity | ||
Genetic divergence between the structures of ZA and BC loops in BD1 vs. BD2 is what allows selective drug targeting of one bromodomain | Genetic divergence between the structures of ZA and BC loops in BD1 vs. BD2 is what allows selective drug targeting of one bromodomain | ||
In BD1, the shortest communication path between ZA and BC loops is a chain consisting of Leu110 Tyr113 Ile117 Asn151 Tyr153 Asn156 [4]. | In BD1, the shortest communication path between ZA and BC loops is a chain consisting of Leu110 Tyr113 Ile117 Asn151 Tyr153 Asn156 [4]. | ||
