Sandbox Reserved 897: Difference between revisions

Line 25:

== Therapheutic features ==

There is no research on the relationship between the BRPF3 PWWP domain and any human disease. However, both of its closely related domains BRPF1 and BRPF2 PWWP domains are associated with hox gene regulation. BRPF1 PWWP domain presents on actively transcribing cells and may regulate Hox A9 gene which is related to MOZ-TIF2-dependant leukemia.<ref>Vezzoli A, Bonadies N, Allen MD, Freund SM, Santiveri CM, Kvinlaug BT, Huntly BJ, Göttgens B, Bycroft M. Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1. Nature structural & molecular biology. 2010 May;17(5):617-9.</ref> BRPF2 is also related to Hox gene wich is associated with schizophrenia and bipolar affective disorder.<ref>Bjarkam CR, Corydon TJ, Olsen IM, Pallesen J, Nyegaard M, Fryland T, Mors O, Børglum AD. Further immunohistochemical characterization of BRD1 a new susceptibility gene for ~~leukemia,~~ schizophrenia, and bipolar affective disorder. Brain Structure and Function. 2009 Dec 1;214(1):37.</ref>~~<ref>Laue K, Daujat S, Crump JG, Plaster N, Roehl HH, Kimmel CB, Schneider R, Hammerschmidt M.~~ The ~~multidomain protein Brpf1 binds histones and is required for~~ Hox gene ~~expression and segmental identity. Development. 2008 Jun 1;135(11):1935~~-~~46.</ref> Therefore BRPF3 PWWP domain, which~~ has very similar β-barrel structure with ~~previous proteins~~, ~~may also have Hox gene-related function. But~~ a further research would be required.

There is no research on the relationship between the BRPF3 PWWP domain and any human disease. However, both of its closely related domains BRPF1 and BRPF2 PWWP domains are associated with hox gene regulation. BRPF1 PWWP domain presents on actively transcribing cells and may regulate Hox A9 gene which is related to MOZ-TIF2-dependant leukemia.<ref>Vezzoli A, Bonadies N, Allen MD, Freund SM, Santiveri CM, Kvinlaug BT, Huntly BJ, Göttgens B, Bycroft M. Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1. Nature structural & molecular biology. 2010 May;17(5):617-9.</ref> BRPF2 is also related to Hox gene wich is associated with schizophrenia and bipolar affective disorder.<ref>Bjarkam CR, Corydon TJ, Olsen IM, Pallesen J, Nyegaard M, Fryland T, Mors O, Børglum AD. Further immunohistochemical characterization of BRD1 a new susceptibility gene for schizophrenia, and bipolar affective disorder. Brain Structure and Function. 2009 Dec 1;214(1):37.</ref> The BRPF3 PWWP domain may also have Hox gene-related function since it has very similar β-barrel structure with its family members. However, a further research would be required for more understandings.

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

Sandbox Reserved 897: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 25: / Line 25: @@
 == Therapheutic features ==
-There is no research on the relationship between the BRPF3 PWWP domain and any human disease. However, both of its closely related domains BRPF1 and BRPF2 PWWP domains are associated with hox gene regulation. BRPF1 PWWP domain presents on actively transcribing cells and may regulate Hox A9 gene which is related to MOZ-TIF2-dependant leukemia.<ref>Vezzoli A, Bonadies N, Allen MD, Freund SM, Santiveri CM, Kvinlaug BT, Huntly BJ, Göttgens B, Bycroft M. Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1. Nature structural & molecular biology. 2010 May;17(5):617-9.</ref> BRPF2 is also related to Hox gene wich is associated with schizophrenia and bipolar affective disorder.<ref>Bjarkam CR, Corydon TJ, Olsen IM, Pallesen J, Nyegaard M, Fryland T, Mors O, Børglum AD. Further immunohistochemical characterization of BRD1 a new susceptibility gene for leukemia, schizophrenia, and bipolar affective disorder. Brain Structure and Function. 2009 Dec 1;214(1):37.</ref><ref>Laue K, Daujat S, Crump JG, Plaster N, Roehl HH, Kimmel CB, Schneider R, Hammerschmidt M. The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity. Development. 2008 Jun 1;135(11):1935-46.</ref> Therefore BRPF3 PWWP domain, which has very similar β-barrel structure with previous proteins, may also have Hox gene-related function. But a further research would be required.
+There is no research on the relationship between the BRPF3 PWWP domain and any human disease. However, both of its closely related domains BRPF1 and BRPF2 PWWP domains are associated with hox gene regulation. BRPF1 PWWP domain presents on actively transcribing cells and may regulate Hox A9 gene which is related to MOZ-TIF2-dependant leukemia.<ref>Vezzoli A, Bonadies N, Allen MD, Freund SM, Santiveri CM, Kvinlaug BT, Huntly BJ, Göttgens B, Bycroft M. Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1. Nature structural & molecular biology. 2010 May;17(5):617-9.</ref> BRPF2 is also related to Hox gene wich is associated with schizophrenia and bipolar affective disorder.<ref>Bjarkam CR, Corydon TJ, Olsen IM, Pallesen J, Nyegaard M, Fryland T, Mors O, Børglum AD. Further immunohistochemical characterization of BRD1 a new susceptibility gene for schizophrenia, and bipolar affective disorder. Brain Structure and Function. 2009 Dec 1;214(1):37.</ref> The BRPF3 PWWP domain may also have Hox gene-related function since it has very similar β-barrel structure with its family members. However, a further research would be required for more understandings.
 This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.