Sandbox Reserved 897: Difference between revisions

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== Overview ==

Bromodomain and PHD finger-containing protein family is the group of proteins found in higher eukaryotes. The members have similar structural features and believed to be an essential part of interaction on H3K36me3.<ref>Vermeulen M, Eberl HC, Matarese F, Marks H, Denissov S, Butter F, Lee KK, Olsen JV, Hyman AA, Stunnenberg HG, Mann M. Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell. 2010 Sep 17;142(6):967-80.</ref> The PWWP motif, a part of BRPF proteins, belongs to the Royal family, which consists of Tudor, chromodomain, MBT(Malignant Brain Tumor), and PWWP domains. The PWWP domain was first identified as a structural motif includes 100 to 130 amino acids in WHSC1 protein research. The researchers named after its very conservative sequence, Pro-Trp-Trp-Pro located at the β2 strand of protein.<ref>Rona GB, Eleutherio EC, Pinheiro AS. PWWP domains and their modes of sensing DNA and histone methylated lysines. Biophysical reviews. 2016 Mar 1;8(1):63-74.</ref> This domain is mainly related to the recognition of methylated histone tail lysine and epigenetic regulation of genes. Unlike BRPF1 and 2, BRPF3 is less studied by the researchers. Therefore many of its function remains unknown.

Bromodomain and PHD finger-containing protein family is the group of proteins found in higher eukaryotes. The members have similar structural features and believed to be an essential part of interaction on H3K36me3.<ref>Vermeulen M, Eberl HC, Matarese F, Marks H, Denissov S, Butter F, Lee KK, Olsen JV, Hyman AA, Stunnenberg HG, Mann M. Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell. 2010 Sep 17;142(6):967-80.</ref> The PWWP motif, a part of BRPF proteins, belongs to the Royal family, which consists of Tudor, chromodomain, MBT(Malignant Brain Tumor), and PWWP domains. The PWWP domain was first identified as a structural motif includes 100 to 130 amino acids in WHSC1 protein research. The researchers named after its very conservative sequence, Pro-Trp-Trp-Pro located at the β2 strand of protein.<ref>Rona GB, Eleutherio EC, Pinheiro AS. PWWP domains and their modes of sensing DNA and histone methylated lysines. Biophysical reviews. 2016 Mar 1;8(1):63-74.</ref> This domain is mainly related to the recognition of specific methylated histone tail lysine and epigenetic regulation of genes. Unlike BRPF1 and 2, BRPF3 is less studied by the researchers. Therefore many of its function remains unknown.

Sandbox Reserved 897: Difference between revisions

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Revision as of 20:09, 28 April 2020 view source Sunsik Chang (talk \| contribs) 57 edits No edit summary ← Older edit		Revision as of 20:20, 28 April 2020 view source Sunsik Chang (talk \| contribs) 57 edits No edit summary Newer edit →
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	== Overview ==		== Overview ==
	Bromodomain and PHD finger-containing protein family is the group of proteins found in higher eukaryotes. The members have similar structural features and believed to be an essential part of interaction on H3K36me3.<ref>Vermeulen M, Eberl HC, Matarese F, Marks H, Denissov S, Butter F, Lee KK, Olsen JV, Hyman AA, Stunnenberg HG, Mann M. Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell. 2010 Sep 17;142(6):967-80.</ref> The PWWP motif, a part of BRPF proteins, belongs to the Royal family, which consists of Tudor, chromodomain, MBT(Malignant Brain Tumor), and PWWP domains. The PWWP domain was first identified as a structural motif includes 100 to 130 amino acids in WHSC1 protein research. The researchers named after its very conservative sequence, Pro-Trp-Trp-Pro located at the β2 strand of protein.<ref>Rona GB, Eleutherio EC, Pinheiro AS. PWWP domains and their modes of sensing DNA and histone methylated lysines. Biophysical reviews. 2016 Mar 1;8(1):63-74.</ref> This domain is mainly related to the recognition of methylated histone tail lysine and epigenetic regulation of genes. Unlike BRPF1 and 2, BRPF3 is less studied by the researchers. Therefore many of its function remains unknown.		Bromodomain and PHD finger-containing protein family is the group of proteins found in higher eukaryotes. The members have similar structural features and believed to be an essential part of interaction on H3K36me3.<ref>Vermeulen M, Eberl HC, Matarese F, Marks H, Denissov S, Butter F, Lee KK, Olsen JV, Hyman AA, Stunnenberg HG, Mann M. Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell. 2010 Sep 17;142(6):967-80.</ref> The PWWP motif, a part of BRPF proteins, belongs to the Royal family, which consists of Tudor, chromodomain, MBT(Malignant Brain Tumor), and PWWP domains. The PWWP domain was first identified as a structural motif includes 100 to 130 amino acids in WHSC1 protein research. The researchers named after its very conservative sequence, Pro-Trp-Trp-Pro located at the β2 strand of protein.<ref>Rona GB, Eleutherio EC, Pinheiro AS. PWWP domains and their modes of sensing DNA and histone methylated lysines. Biophysical reviews. 2016 Mar 1;8(1):63-74.</ref> This domain is mainly related to the recognition of specific methylated histone tail lysine and epigenetic regulation of genes. Unlike BRPF1 and 2, BRPF3 is less studied by the researchers. Therefore many of its function remains unknown.