Sandbox Reserved 897: Difference between revisions

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=== Evolutionary conservations ===

PWWP domain is only found in eukaryotes, from a yeast to a human. The number of PWWP containing protein varies on species; a man has 20 PWWP containing proteins. The loyal family has a common structural characteristic, three conserved β-strands.<ref>Rona GB, Eleutherio EC, Pinheiro AS. PWWP domains and their modes of sensing DNA and histone methylated lysines. Biophysical reviews. 2016 Mar 1;8(1):63-74.</ref> Therefore, PWWP domains are believed to be evolved from a common ancestor which had 3 β-strands. Using the domain-tree approach, the BRPF family has branched out from rest of PWWP domain-containing proteins early and evolved itself.<ref>Alvarez-Venegas R, Avramova Z. Evolution of the PWWP-domain encoding genes in the plant and animal lineages. BMC evolutionary biology. 2012 Dec 1;12(1):101.</ref> As a domain, the PWWP presents in both unicellular and multicellular organisms. However, proteins of unicellular organisms are not found in multicellular creatures. Therefore, the PWWP domain was transmitted as a conserved linear arrangement alone, not with the whole protein.<ref>Alvarez-Venegas R, Avramova Z. Evolution of the PWWP-domain encoding genes in the plant and animal lineages. BMC evolutionary biology. 2012 Dec 1;12(1):101.</ref>

PWWP domain is only found in eukaryotes, from a yeast to a human. The number of PWWP containing protein varies on species; a man has 20 PWWP containing proteins. The loyal family has a common structural characteristic, three conserved β-strands.<ref>Rona GB, Eleutherio EC, Pinheiro AS. PWWP domains and their modes of sensing DNA and histone methylated lysines. Biophysical reviews. 2016 Mar 1;8(1):63-74.</ref> Therefore, PWWP domains are believed to be evolved from a common ancestor which had 3 β-strands. Using the domain-tree approach, it is suggested that the BRPF family has branched out from rest of PWWP domain-containing proteins early and evolved itself.<ref>Alvarez-Venegas R, Avramova Z. Evolution of the PWWP-domain encoding genes in the plant and animal lineages. BMC evolutionary biology. 2012 Dec 1;12(1):101.</ref> As a domain, the PWWP presents in both unicellular and multicellular organisms. However, proteins of unicellular organisms are not found in multicellular creatures. Therefore, the PWWP domain was transmitted as a conserved linear arrangement alone, not with the whole protein.<ref>Alvarez-Venegas R, Avramova Z. Evolution of the PWWP-domain encoding genes in the plant and animal lineages. BMC evolutionary biology. 2012 Dec 1;12(1):101.</ref>

== Therapheutic features ==

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 === Evolutionary conservations ===
-PWWP domain is only found in eukaryotes, from a yeast to a human. The number of PWWP containing protein varies on species; a man has 20 PWWP containing proteins. The loyal family has a common structural characteristic, three conserved β-strands.<ref>Rona GB, Eleutherio EC, Pinheiro AS. PWWP domains and their modes of sensing DNA and histone methylated lysines. Biophysical reviews. 2016 Mar 1;8(1):63-74.</ref> Therefore, PWWP domains are believed to be evolved from a common ancestor which had 3 β-strands. Using the domain-tree approach, the BRPF family has branched out from rest of PWWP domain-containing proteins early and evolved itself.<ref>Alvarez-Venegas R, Avramova Z. Evolution of the PWWP-domain encoding genes in the plant and animal lineages. BMC evolutionary biology. 2012 Dec 1;12(1):101.</ref> As a domain, the PWWP presents in both unicellular and multicellular organisms. However, proteins of unicellular organisms are not found in multicellular creatures. Therefore, the PWWP domain was transmitted as a conserved linear arrangement alone, not with the whole protein.<ref>Alvarez-Venegas R, Avramova Z. Evolution of the PWWP-domain encoding genes in the plant and animal lineages. BMC evolutionary biology. 2012 Dec 1;12(1):101.</ref>
+PWWP domain is only found in eukaryotes, from a yeast to a human. The number of PWWP containing protein varies on species; a man has 20 PWWP containing proteins. The loyal family has a common structural characteristic, three conserved β-strands.<ref>Rona GB, Eleutherio EC, Pinheiro AS. PWWP domains and their modes of sensing DNA and histone methylated lysines. Biophysical reviews. 2016 Mar 1;8(1):63-74.</ref> Therefore, PWWP domains are believed to be evolved from a common ancestor which had 3 β-strands. Using the domain-tree approach, it is suggested that the BRPF family has branched out from rest of PWWP domain-containing proteins early and evolved itself.<ref>Alvarez-Venegas R, Avramova Z. Evolution of the PWWP-domain encoding genes in the plant and animal lineages. BMC evolutionary biology. 2012 Dec 1;12(1):101.</ref> As a domain, the PWWP presents in both unicellular and multicellular organisms. However, proteins of unicellular organisms are not found in multicellular creatures. Therefore, the PWWP domain was transmitted as a conserved linear arrangement alone, not with the whole protein.<ref>Alvarez-Venegas R, Avramova Z. Evolution of the PWWP-domain encoding genes in the plant and animal lineages. BMC evolutionary biology. 2012 Dec 1;12(1):101.</ref>
 == Therapheutic features ==