User:Allie Pointer/Pointer Sandbox 1: Difference between revisions
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== Background == | == Background == | ||
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IL-12 is proinflammatory meaning it promotes inflammation which contributes in developing th1 cells from th0 cells. <ref name="family">PMID:22814351</ref> It also participates in a positive feed back loop. IL-12 caused interferon gamma production from t cells. That facilitated th1 differentiation. IL-12 also induced production of interferon gamma by natural killer cells. <ref name="family" /> Interferon gamma can be a part of the positive feed back loop because transcription factors are activated. In a study done on mice, if specific transcription factors are not expressed than there can be a defect in one or both subunits of IL-12. <ref name="cytokines">PMID:19275692 </ref> | IL-12 is proinflammatory meaning it promotes inflammation which contributes in developing th1 cells from th0 cells. <ref name="family">PMID:22814351</ref> It also participates in a positive feed back loop. IL-12 caused interferon gamma production from t cells. That facilitated th1 differentiation. IL-12 also induced production of interferon gamma by natural killer cells. <ref name="family" /> Interferon gamma can be a part of the positive feed back loop because transcription factors are activated. In a study done on mice, if specific transcription factors are not expressed than there can be a defect in one or both subunits of IL-12. <ref name="cytokines">PMID:19275692 </ref> | ||
== Diseases == | == Diseases == | ||
