DNA Polymerase Theta: Difference between revisions
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==Sequence Conservation== | ==Sequence Conservation== | ||
The sequence of QM1 is highly conserved as it belongs to a distinct family of polymerases. The majority of conserved residues reside in the interior of the channel that contacts the DNA and incoming nucleotide indicating that these regions are critical to polymerase function. Less sequence conservation is observed in the exterior alpha helices as the residues are exposed at the surface and alpha helices can tolerate more variation in amino acid composition than other secondary structural elements. | The sequence of QM1 is highly conserved as it belongs to a distinct family of polymerases. The majority of conserved residues reside in the interior of the channel that contacts the DNA and incoming nucleotide indicating that these regions are critical to polymerase function. Less sequence conservation is observed in the exterior alpha helices as the residues are exposed at the surface and alpha helices can tolerate more variation in amino acid composition than other secondary structural elements. | ||
[[Image:4X0Pconsurf.jpg]] | [[Image:4X0Pconsurf.jpg | thumb | center | 300px]] | ||
==Relevance== | ==Relevance== | ||
Polymerase theta over-expression in a number of cancers including breast cancer, non-small cell lung cancer, and oral squamous cell carcinoma is correlated with poor survival rates. Due to the role polymerase theta plays in double strand break repair, cells that over express polymerase theta are better able to repair damage caused by ionizing radiation treatment and chemotherapy. By developing compounds that inhibit polymerase theta activity in cancer cells, traditional cancer therapies can be made more effective in cancers that express high levels of polymerase theta. | |||
== References == | == References == | ||
<references/> | <references/> | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
