Synapsin

spinqualitylabelsall models Rat synapsin 1 complex with ATP and Ca++ ion (green) (PDB code 1px2) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Synapsins (SYN) are neuronal phosphoproteins which modulate neurotransmitter release at the pre-synaptic terminal by reversibly tethering synaptic vescicles to the actin cytoskeleton. Structural highlights The 3D structure of the rat synapsin 1 complex with ATP shows the catalytically essential multifunctional loop surrounding the ATP which makes both hydrogen bonds and Van-der Waals contacts with the protein. Water molecules are shown as red spheres.

3D structures of synapsin

Updated on 30-April-2020

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• Synapsin 1
  • 1auv - bSYN1A C-terminal 110-421 - bovine
    
  • 1aux - bSYN1A C-terminal + ATPgS
    
  • 1pk8, 1px2 - rSYN1 + ATP - rat
    
• Synapsin 2
  • 1i7n - rSYN2 C-terminal
    
  • 1i7l - rSYN2 C-terminal + ATP
    
• Synapsin 3
  • 2p0a - hSYN3 actin-binding+synaptic vescicle binding domains 76-417 + AMPPNP - human
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky