1b8e: Difference between revisions

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[[Image:1b8e.~~gif~~|left|200px]]

[[Image:1b8e.png|left|200px]]

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~~'''~~HIGH RESOLUTION CRYSTAL STRUCTURE OF THE BOVINE BETA-LACTOGLOBULIN (ISOFORMS A AND B) IN ORTHOROMBIC SPACE GROUP~~'''~~

===HIGH RESOLUTION CRYSTAL STRUCTURE OF THE BOVINE BETA-LACTOGLOBULIN (ISOFORMS A AND B) IN ORTHOROMBIC SPACE GROUP===

~~==Overview==~~

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The ~~crystal structures of beta-lactoglobulin genetic variants A and B have been determined in the orthorhombic space group C222(1) (lattice Y) by X-ray diffraction at 2.0 A and 1.95 A resolution~~, ~~respectively. The structural comparison shows that both variants exhibit~~ the ~~open conformation of~~ the ~~EF loop at the pH of crystallization~~ (~~pH 7.9), in contrast to what has been reported for the same genetic variants~~ at ~~pH 7~~.~~1 in the trigonal space group P3221 (lattice Z) [Qin, B~~.~~Y., Bewley, M.C., Creamer, L.K., Baker, E.N. & Jameson, G.B. (1999~~) ~~Protein Sci. 8, 75-83]. Furthermore~~, ~~it was found that~~ the stereochemical environment of Tyr42 changes significantly with pH variation between pH 7 and pH 8. This may provide a structural explanation for an as yet unexplained feature of the Tanford transition, namely the increase in exposure of a tyrosine residue.

The line below this paragraph, {{ABSTRACT_PUBMED_11168385}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11168385 is the PubMed ID number.

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==About this Structure==

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[[Category: Lipocalin]]

[[Category: Variant]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 11~~:12:01 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:33:08 2008''

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-[[Image:1b8e.gif|left|200px]]
+{{Seed}}
+[[Image:1b8e.png|left|200px]]
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 {{STRUCTURE_1b8e|  PDB=1b8e  |  SCENE=  }}
-'''HIGH RESOLUTION CRYSTAL STRUCTURE OF THE BOVINE BETA-LACTOGLOBULIN (ISOFORMS A AND B) IN ORTHOROMBIC SPACE GROUP'''
+===HIGH RESOLUTION CRYSTAL STRUCTURE OF THE BOVINE BETA-LACTOGLOBULIN (ISOFORMS A AND B) IN ORTHOROMBIC SPACE GROUP===
-==Overview==
+<!--
-The crystal structures of beta-lactoglobulin genetic variants A and B have been determined in the orthorhombic space group C222(1) (lattice Y) by X-ray diffraction at 2.0 A and 1.95 A resolution, respectively. The structural comparison shows that both variants exhibit the open conformation of the EF loop at the pH of crystallization (pH 7.9), in contrast to what has been reported for the same genetic variants at pH 7.1 in the trigonal space group P3221 (lattice Z) [Qin, B.Y., Bewley, M.C., Creamer, L.K., Baker, E.N. &amp; Jameson, G.B. (1999) Protein Sci. 8, 75-83]. Furthermore, it was found that the stereochemical environment of Tyr42 changes significantly with pH variation between pH 7 and pH 8. This may provide a structural explanation for an as yet unexplained feature of the Tanford transition, namely the increase in exposure of a tyrosine residue.
+The line below this paragraph, {{ABSTRACT_PUBMED_11168385}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11168385 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11168385}}
 ==About this Structure==
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 [[Category: Lipocalin]]
 [[Category: Variant]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:12:01 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:33:08 2008''