5fh6: Difference between revisions

<table><tr><td colspan='2'>[[5fh6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FH6 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5XM:(3~{R})-3-(PIPERIDIN-1-YLMETHYL)-2,3-DIHYDRO-1~{H}-PYRROLO[1,2-A]QUINAZOLIN-5-ONE'>5XM</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fh6 OCA], [https://pdbe.org/5fh6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fh6 RCSB], [https://www.ebi.ac.uk/pdbsum/5fh6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fh6 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>  

[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>  

[[Category: Homo sapiens]]

[[Category: Arrowsmith CH]]

[[Category: Bountra C]]

[[Category: Brennan PE]]

[[Category: Edwards AM]]

[[Category: Fedorov O]]

[[Category: Fonseca M]]

[[Category: Knapp S]]

[[Category: Krojer T]]

[[Category: Ley SV]]

[[Category: Picaud S]]

[[Category: Siejka P]]

[[Category: Sutherell CL]]

[[Category: Tallant C]]

[[Category: Von Delft F]]