CFTR inhibitory factor: Difference between revisions
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<StructureSection load='5tnh' size='340' side='right' caption=' | <StructureSection load='5tnh' size='340' side='right' caption='CFTR inhibitory factor complex with an intermediate (PDB code [[5tnh]])' scene=''> | ||
== Function == | == Function == | ||
''' | '''CFTR inhibitory factor''' (Cif) is a virulance factor which catalyzes epoxide hydrolysis. ''Pseudomonas aeruginosa'' secretes Cif which causes the loss the ion channel Cystic Fibrosis Transmembrane conductance Regulator (CFTR) which is required for airway mucocilliary defense of the host cell<ref>PMID:26136396</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
The 3D structure of the complex between Cif and the epoxy hydrolysis intermediate shows the coordination by His and Tyr esidues which facilitate the epoxyde opening by a nucleophilic attack of Asp creating a hydroxyalkyl-enzyme intermediate<ref>PMID:28392259</ref>. | |||
</StructureSection> | </StructureSection> | ||
Revision as of 08:35, 7 May 2020
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3D structures of CTFR inhibitory factor
Updated on 07-May-2020
3kd2 - PaCif - Pseudomonas aeruginosa
3kda, 4dm7, 4dln, 4dmf, 4dmh, 4dmk, 3pi6, 4dmc - PaCif (mutant)
5tnh, 5tng, 5tni, 5tnl, 5tnk, 5tnn, 5tnm, 5tnd, 5tnf, 5tne, 5tnp, 5tnr, 5tnq, 5tns, 5tnj, 5jyc, 4dno, 4dnf - PaCif (mutant) + intermediate
4ehb - PaCif (mutant) + epoxyhexane
4eus - PaCif + hexanediol
4yx9, 5hka, 5hkb, 5hk9 - PaCif + inhibitor
