1b9k: Difference between revisions

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[[Image:1b9k.gif|left|200px]]
{{Seed}}
[[Image:1b9k.png|left|200px]]


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{{STRUCTURE_1b9k|  PDB=1b9k  |  SCENE=  }}  
{{STRUCTURE_1b9k|  PDB=1b9k  |  SCENE=  }}  


'''ALPHA-ADAPTIN APPENDAGE DOMAIN, FROM CLATHRIN ADAPTOR AP2'''
===ALPHA-ADAPTIN APPENDAGE DOMAIN, FROM CLATHRIN ADAPTOR AP2===




==Overview==
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The alpha subunit of the endocytotic AP2 adaptor complex contains a 30 kDa "appendage" domain, which is joined to the rest of the protein via a flexible linker. The 1.9 A resolution crystal structure of this domain reveals a single binding site for its ligands, which include amphiphysin, Eps15, and epsin. This domain when overexpressed in COS7 fibroblasts is shown to inhibit transferrin uptake, whereas mutants in which interactions with its binding partners are abolished do not. DPF/W motifs present in appendage domain-binding partners are shown to play a crucial role in their interactions with the domain. A single site for binding multiple ligands would allow for temporal and spatial regulation in the recruitment of components of the endocytic machinery.
The line below this paragraph, {{ABSTRACT_PUBMED_10380931}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_10380931}}


==About this Structure==
==About this Structure==
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[[Category: Adaptor]]
[[Category: Adaptor]]
[[Category: Endocytosis]]
[[Category: Endocytosis]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:14:41 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:38:15 2008''
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