1b9y: Difference between revisions

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[[Image:1b9y.~~gif~~|left|200px]]

[[Image:1b9y.png|left|200px]]

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~~'''~~STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN BETA-GAMMA~~'''~~

===STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN BETA-GAMMA===

~~==Overview==~~

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~~Visual signal transduction is a nearly noise-free process that is exquisitely well regulated over a wide dynamic range of light intensity. A key component in dark/light adaptation is phosducin~~, ~~a phosphorylatable protein that modulates~~ the ~~amount of transducin heterotrimer (Gt alpha beta gamma) available through sequestration of~~ the ~~beta gamma subunits~~ (~~Gt beta gamma)~~. The structure of the phosphophosducin/Gt beta gamma complex combined with mutational and biophysical analysis provides a stereochemical mechanism for the regulation of the phosducin-Gt beta gamma interaction. ~~Phosphorylation of serine 73 causes an order-to-disorder transition of a 20-residue stretch~~, ~~including~~ the ~~phosphorylation site, by disrupting a helix~~-capping motif. This transition disrupts phosducin's interface with Gt beta gamma, leading to the release of unencumbered Gt beta gamma, which reassociates with the membrane and Gt alpha to form a signaling-~~competent Gt alpha beta gamma heterotrimer.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10360181}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10360181 is the PubMed ID number.

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==About this Structure==

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[[Category: Transducin]]

[[Category: Vision]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 11~~:15:40 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:39:48 2008''

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-[[Image:1b9y.gif|left|200px]]
+{{Seed}}
+[[Image:1b9y.png|left|200px]]
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 {{STRUCTURE_1b9y|  PDB=1b9y  |  SCENE=  }}
-'''STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN BETA-GAMMA'''
+===STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN BETA-GAMMA===
-==Overview==
+<!--
-Visual signal transduction is a nearly noise-free process that is exquisitely well regulated over a wide dynamic range of light intensity. A key component in dark/light adaptation is phosducin, a phosphorylatable protein that modulates the amount of transducin heterotrimer (Gt alpha beta gamma) available through sequestration of the beta gamma subunits (Gt beta gamma). The structure of the phosphophosducin/Gt beta gamma complex combined with mutational and biophysical analysis provides a stereochemical mechanism for the regulation of the phosducin-Gt beta gamma interaction. Phosphorylation of serine 73 causes an order-to-disorder transition of a 20-residue stretch, including the phosphorylation site, by disrupting a helix-capping motif. This transition disrupts phosducin's interface with Gt beta gamma, leading to the release of unencumbered Gt beta gamma, which reassociates with the membrane and Gt alpha to form a signaling-competent Gt alpha beta gamma heterotrimer.
+The line below this paragraph, {{ABSTRACT_PUBMED_10360181}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10360181 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10360181}}
 ==About this Structure==
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 [[Category: Transducin]]
 [[Category: Vision]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:15:40 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:39:48 2008''