6osh: Difference between revisions

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<StructureSection load='6osh' size='340' side='right'caption='[[6osh]], [[Resolution|resolution]] 1.12&Aring;' scene=''>
<StructureSection load='6osh' size='340' side='right'caption='[[6osh]], [[Resolution|resolution]] 1.12&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6osh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OSH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6OSH FirstGlance]. <br>
<table><tr><td colspan='2'>[[6osh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OSH FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ROR2, NTRKR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.117&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6osh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6osh OCA], [https://pdbe.org/6osh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6osh RCSB], [https://www.ebi.ac.uk/pdbsum/6osh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6osh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6osh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6osh OCA], [http://pdbe.org/6osh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6osh RCSB], [http://www.ebi.ac.uk/pdbsum/6osh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6osh ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/ROR2_HUMAN ROR2_HUMAN]] Autosomal recessive Robinow syndrome;Brachydactyly type B. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/ROR2_HUMAN ROR2_HUMAN] Autosomal recessive Robinow syndrome;Brachydactyly type B. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ROR2_HUMAN ROR2_HUMAN]] Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation.<ref>PMID:17717073</ref>
[https://www.uniprot.org/uniprot/ROR2_HUMAN ROR2_HUMAN] Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation.<ref>PMID:17717073</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6osh" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6osh" style="background-color:#fffaf0;"></div>
==See Also==
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
*[[3D structures of non-human antibody|3D structures of non-human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: European rabbit]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Oryctolagus cuniculus]]
[[Category: Park, H]]
[[Category: Park H]]
[[Category: Rader, C]]
[[Category: Rader C]]
[[Category: Antibody]]
[[Category: Immune system]]
[[Category: Kringle domain]]
[[Category: Phage display]]
[[Category: Receptor tyrosine kinase-like orphan receptor]]
[[Category: Ror2]]
[[Category: Scfv]]
[[Category: Single chain fv]]
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