1bbd: Difference between revisions

Line 1:

[[Image:1bbd.~~gif~~|left|200px]]

[[Image:1bbd.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~THREE DIMENSIONAL STRUCTURE OF THE FAB FRAGMENT OF A NEUTRALIZING ANTIBODY TO HUMAN RHINOVIRUS SEROTYPE 2~~'''~~

===THREE DIMENSIONAL STRUCTURE OF THE FAB FRAGMENT OF A NEUTRALIZING ANTIBODY TO HUMAN RHINOVIRUS SEROTYPE 2===

~~==Overview==~~

<!--

The ~~crystal structure of the antigen-binding fragment of a monoclonal antibody (8F5) that neutralizes human rhinovirus serotype 2 has been determined by X-ray diffraction studies. Antibody 8F5~~, ~~obtained by immunization with native HRV2 virions~~, ~~cross-reacts with peptides of~~ the ~~viral capsid protein VP2, which contribute~~ to the ~~neutralizing immunogenic site B in this serotype. The structure was solved by the molecular replacement method and has been refined to an R-factor of 18.9%~~ at 2.~~8 A resolution~~. ~~The elbow angle~~, ~~relating the variable and constant modules of the molecule~~ is ~~127 degrees, representing~~ the ~~smallest elbow angle observed so far in an Fab fragment~~. ~~Furthermore, the charged residues of the epitope can be well accommodated in the antigen~~-~~binding site. This is the first crystal structure reported for an antibody directed against an icosahedral virus.~~

The line below this paragraph, {{ABSTRACT_PUBMED_1338980}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 1338980 is the PubMed ID number.

-->

==About this Structure==

Line 25:

Line 29:

[[Category: Tormo, J.]]

[[Category: Immunoglobulin]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 11~~:18:17 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:45:38 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1bbd.gif|left|200px]]
+{{Seed}}
+[[Image:1bbd.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1bbd|  PDB=1bbd  |  SCENE=  }}
-'''THREE DIMENSIONAL STRUCTURE OF THE FAB FRAGMENT OF A NEUTRALIZING ANTIBODY TO HUMAN RHINOVIRUS SEROTYPE 2'''
+===THREE DIMENSIONAL STRUCTURE OF THE FAB FRAGMENT OF A NEUTRALIZING ANTIBODY TO HUMAN RHINOVIRUS SEROTYPE 2===
-==Overview==
+<!--
-The crystal structure of the antigen-binding fragment of a monoclonal antibody (8F5) that neutralizes human rhinovirus serotype 2 has been determined by X-ray diffraction studies. Antibody 8F5, obtained by immunization with native HRV2 virions, cross-reacts with peptides of the viral capsid protein VP2, which contribute to the neutralizing immunogenic site B in this serotype. The structure was solved by the molecular replacement method and has been refined to an R-factor of 18.9% at 2.8 A resolution. The elbow angle, relating the variable and constant modules of the molecule is 127 degrees, representing the smallest elbow angle observed so far in an Fab fragment. Furthermore, the charged residues of the epitope can be well accommodated in the antigen-binding site. This is the first crystal structure reported for an antibody directed against an icosahedral virus.
+The line below this paragraph, {{ABSTRACT_PUBMED_1338980}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 1338980 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_1338980}}
 ==About this Structure==
@@ Line 25: / Line 29: @@
 [[Category: Tormo, J.]]
 [[Category: Immunoglobulin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:18:17 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:45:38 2008''