User:Andre Wu Le Chun/Sandbox 1

Prefusion 2019-nCoV spike glycoprotein with a single receptor-binding domain up

spinqualitylabelsall models 2019-nCoV spike glycoprotein with a single receptor-binding domain up. 6vsb Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D This is a default text for your page Andre Wu Le Chun/Sandbox 1. Click above on edit this page to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia or to the article describing Jmol to the rescue. Structural highlights 6vsb is a trimeric glycoprotein with 3 chains in it's structure. There are two subunits which are fundamental for the virus entry in the cell: the S1 subunit and the S2 subunit. Function The spike glycoprotein reconizes the hosts cell's angiotensin-converting enzime 2 (ACE2) receptor and binds itself on it, allowing the fusion of viral and cellular membrane. Disease 6vsb is a protein related to the virus entry in the cell. Therefore, has an enormous role on the new coronavirus pandemic, in 2020. Relevance Potential target for antibodies. Development of vaccines based on the structure of the protein and on it's recognition/biding mechanisms. Interaction with angiotensin-converting enzime 2 receptor The interaction between the 2019-nCov and the host cell begins with the recognition of the ACE2 receptor. Then, the S1 subunit moves, modifying the protein's conformation in way that determinants for the virus-cell binding. Due to the conformational movements, the protein structure assumes a conformation which is suitable for binding with the ACE2 receptor. At that instance, the spike protein is found in a "up" conformation, hence the protein's name. This is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

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Andre Wu Le Chun