6s6w: Difference between revisions

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<StructureSection load='6s6w' size='340' side='right'caption='[[6s6w]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
<StructureSection load='6s6w' size='340' side='right'caption='[[6s6w]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6s6w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S6W OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6S6W FirstGlance]. <br>
<table><tr><td colspan='2'>[[6s6w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S6W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S6W FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KXT:2,6-diphenylimidazo[1,2-a]pyridine'>KXT</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ALDH1A3, ALDH6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KXT:2,6-diphenylimidazo[1,2-a]pyridine'>KXT</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Retinal_dehydrogenase Retinal dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.36 1.2.1.36] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s6w OCA], [https://pdbe.org/6s6w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s6w RCSB], [https://www.ebi.ac.uk/pdbsum/6s6w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s6w ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6s6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s6w OCA], [http://pdbe.org/6s6w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s6w RCSB], [http://www.ebi.ac.uk/pdbsum/6s6w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s6w ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/AL1A3_HUMAN AL1A3_HUMAN]] Isolated anophthalmia - microphthalmia. The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/AL1A3_HUMAN AL1A3_HUMAN] Isolated anophthalmia - microphthalmia. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/AL1A3_HUMAN AL1A3_HUMAN]] Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity).  
[https://www.uniprot.org/uniprot/AL1A3_HUMAN AL1A3_HUMAN] Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6s6w" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6s6w" style="background-color:#fffaf0;"></div>
==See Also==
*[[Aldehyde dehydrogenase 3D structures|Aldehyde dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Retinal dehydrogenase]]
[[Category: Ferraris DM]]
[[Category: Ferraris, D M]]
[[Category: Garavaglia S]]
[[Category: Garavaglia, S]]
[[Category: Gelardi ELM]]
[[Category: Gelardi, E L.M]]
[[Category: LaMotta C]]
[[Category: LaMotta, C]]
[[Category: Quattrini L]]
[[Category: Quattrini, L]]
[[Category: Aldh1a3 ga11 glioma 2]]
[[Category: Cytosolic protein]]
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