1bfw: Difference between revisions

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[[Image:1bfw.gif|left|200px]]
{{Seed}}
[[Image:1bfw.png|left|200px]]


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{{STRUCTURE_1bfw|  PDB=1bfw  |  SCENE=  }}  
{{STRUCTURE_1bfw|  PDB=1bfw  |  SCENE=  }}  


'''RETRO-INVERSO ANALOGUE OF THE G-H LOOP OF VP1 IN FOOT-AND-MOUTH-DISEASE (FMD) VIRUS, NMR, 10 STRUCTURES'''
===RETRO-INVERSO ANALOGUE OF THE G-H LOOP OF VP1 IN FOOT-AND-MOUTH-DISEASE (FMD) VIRUS, NMR, 10 STRUCTURES===




==Overview==
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The antigenic activity of a 19-mer peptide corresponding to the major antigenic region of foot-and-mouth disease virus and its retro-enantiomeric analogue was found to be completely abolished when they were tested in a biosensor system in trifluoroethanol. This suggests that the folding pattern, which is alpha-helix in trifluoroethanol (confirmed by CD measurement), does not correspond to the biologically relevant conformation(s) recognized by antibodies. The NMR structures of both peptides were thus determined in aqueous solution. These studies showed that the two peptides exhibit similar folding features, particularly in their C termini. This may explain in part the cross-reactive properties of the two peptides in aqueous solution. However, the retro-inverso analogue appears to be more rigid than the parent peptide and contains five atypical beta-turns. This feature may explain why retro-inverso foot-and-mouth disease virus peptides are often better recognized than the parent peptide by anti-virion antibodies.
The line below this paragraph, {{ABSTRACT_PUBMED_9920919}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9920919 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9920919}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFW OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFW OCA].  


==Reference==
==Reference==
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[[Category: Peptidomimetic]]
[[Category: Peptidomimetic]]
[[Category: Retro-inverso]]
[[Category: Retro-inverso]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:27:36 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:04:16 2008''

Revision as of 16:04, 30 June 2008

File:1bfw.png

Template:STRUCTURE 1bfw

RETRO-INVERSO ANALOGUE OF THE G-H LOOP OF VP1 IN FOOT-AND-MOUTH-DISEASE (FMD) VIRUS, NMR, 10 STRUCTURES

Template:ABSTRACT PUBMED 9920919

About this Structure

Full experimental information is available from OCA.

Reference

Solution structure of a retro-inverso peptide analogue mimicking the foot-and-mouth disease virus major antigenic site. Structural basis for its antigenic cross-reactivity with the parent peptide., Petit MC, Benkirane N, Guichard G, Du AP, Marraud M, Cung MT, Briand JP, Muller S, J Biol Chem. 1999 Feb 5;274(6):3686-92. PMID:9920919

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