6mqk: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[6mqk]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQK OCA]. For a guided tour on the structure components use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6MQK FirstGlance].

<table><tr><td colspan='2'>[[6mqk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQK OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=6MQK FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">SEPT12 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">SEPT12 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[~~http~~://proteopedia.org/fgij/fg.htm?mol=6mqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mqk OCA], [~~http~~://pdbe.org/6mqk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6mqk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6mqk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6mqk ProSAT]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=6mqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mqk OCA], [https://pdbe.org/6mqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mqk RCSB], [https://www.ebi.ac.uk/pdbsum/6mqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mqk ProSAT]</td></tr>

</table>

== Disease ==

[[~~http~~://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Non-syndromic male infertility due to sperm motility disorder. The disease is caused by mutations affecting the gene represented in this entry.

[[https://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Non-syndromic male infertility due to sperm motility disorder. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[[~~http~~://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in cytokinesis (Potential).<ref>PMID:24213608</ref> <ref>PMID:25588830</ref>

[[https://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in cytokinesis (Potential).<ref>PMID:24213608</ref> <ref>PMID:25588830</ref>

== Publication Abstract from PubMed ==

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 <StructureSection load='6mqk' size='340' side='right'caption='[[6mqk]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6mqk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6MQK FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6mqk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MQK FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SEPT12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SEPT12 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6mqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mqk OCA], [http://pdbe.org/6mqk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mqk RCSB], [http://www.ebi.ac.uk/pdbsum/6mqk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mqk ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mqk OCA], [https://pdbe.org/6mqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mqk RCSB], [https://www.ebi.ac.uk/pdbsum/6mqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mqk ProSAT]</span></td></tr>
 </table>
 == Disease ==
-[[http://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Non-syndromic male infertility due to sperm motility disorder. The disease is caused by mutations affecting the gene represented in this entry.
+[[https://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Non-syndromic male infertility due to sperm motility disorder. The disease is caused by mutations affecting the gene represented in this entry.
 == Function ==
-[[http://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in cytokinesis (Potential).<ref>PMID:24213608</ref> <ref>PMID:25588830</ref>
+[[https://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in cytokinesis (Potential).<ref>PMID:24213608</ref> <ref>PMID:25588830</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==