2pku: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[2pku]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PKU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2PKU FirstGlance]. <br>

<table><tr><td colspan='2'>[[2pku]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PKU FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2pku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pku OCA], [~~http~~://pdbe.org/2pku PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2pku RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2pku PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2pku ProSAT]</span></td></tr>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pku OCA], [https://pdbe.org/2pku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pku RCSB], [https://www.ebi.ac.uk/pdbsum/2pku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pku ProSAT]</span></td></tr>

</table>

== Function ==

[[~~http~~://www.uniprot.org/uniprot/PICK1_RAT PICK1_RAT]] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel.<ref>PMID:16138078</ref>

[[https://www.uniprot.org/uniprot/PICK1_RAT PICK1_RAT]] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel.<ref>PMID:16138078</ref>

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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 <StructureSection load='2pku' size='340' side='right'caption='[[2pku]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2pku]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PKU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2PKU FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2pku]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PKU FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2pku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pku OCA], [http://pdbe.org/2pku PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pku RCSB], [http://www.ebi.ac.uk/pdbsum/2pku PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pku ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pku OCA], [https://pdbe.org/2pku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pku RCSB], [https://www.ebi.ac.uk/pdbsum/2pku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pku ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/PICK1_RAT PICK1_RAT]] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel.<ref>PMID:16138078</ref>
+[[https://www.uniprot.org/uniprot/PICK1_RAT PICK1_RAT]] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel.<ref>PMID:16138078</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]