5ixf: Difference between revisions

<StructureSection load='5ixf' size='340' side='right'caption='[[5ixf]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[5ixf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IXF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IXF FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STAM2, HBP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ixf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ixf OCA], [http://pdbe.org/5ixf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ixf RCSB], [http://www.ebi.ac.uk/pdbsum/5ixf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ixf ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/STAM2_HUMAN STAM2_HUMAN]] Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).  

[[Category: Human]]

[[Category: Cantrelle, F X]]

[[Category: Hologne, M]]

[[Category: Trivelli, X]]

[[Category: Walker, O]]

[[Category: Traffic]]