5jab: Difference between revisions

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<StructureSection load='5jab' size='340' side='right'caption='[[5jab]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
<StructureSection load='5jab' size='340' side='right'caption='[[5jab]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5jab]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JAB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JAB FirstGlance]. <br>
<table><tr><td colspan='2'>[[5jab]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JAB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6J4:COENZYME+F420-3'>6J4</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jab OCA], [http://pdbe.org/5jab PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jab RCSB], [http://www.ebi.ac.uk/pdbsum/5jab PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jab ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6J4:COENZYME+F420-3'>6J4</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jab OCA], [https://pdbe.org/5jab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jab RCSB], [https://www.ebi.ac.uk/pdbsum/5jab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jab ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FBVR_MYCTU FBVR_MYCTU] Catalyzes the F420H(2)-dependent reduction of biliverdin-IXalpha at C10 position, leading to bilirubin-IXalpha, a potent antioxidant. As biliverdin-IXalpha is produced in high amounts in macrophages infected with M.tuberculosis, its reduction by Rv2074 may play a role in protecting mycobacteria against oxidative stress, aiding the persistence of M.tuberculosis infection.<ref>PMID:27364382</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ahmed, F H]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Carr, P D]]
[[Category: Ahmed FH]]
[[Category: Jackson, C J]]
[[Category: Carr PD]]
[[Category: Biliverdin reductase]]
[[Category: Jackson CJ]]
[[Category: F420 binding protein]]
[[Category: Flavin/deazaflavin oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Split beta-barrel fold]]
Retrieved from "https://proteopedia.org/5jab"