User:Andre Wu Le Chun/Sandbox 1: Difference between revisions
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== Function == | == Function == | ||
The spike glycoprotein | The spike glycoprotein recognizes the hosts cell's angiotensin-converting enzime 2 (ACE2) and binds itself on it, allowing the fusion of viral and cellular membrane, therefore enabling the viral infection. | ||
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== Relevance == | == Relevance == | ||
Due to its role in the infection process, the spike glyprotein may be a potential target of studies that seek methods of preventing the COVID-19 disease. These include the development of vaccines based on the protein's structure of the protein and on it's recognition/biding mechanisms. For instance, avoiding the cleavage of the furin, located on the B domains of the protein, by the host's proteases could be a way of viral inhibition. | |||
== Interaction with angiotensin-converting enzime 2 | == Interaction with angiotensin-converting enzime 2 == | ||
The interaction between the 2019-nCov and the host cell begins with the recognition of the ACE2 receptor. Then, the S1 subunit moves, modifying the protein's conformation in way that determinants for the virus-cell binding. Due to the conformational movements, the protein structure assumes a conformation which is suitable for binding with the ACE2 receptor. At that instance, the spike protein is found in a "up" conformation, hence the protein's name. | The interaction between the 2019-nCov and the host cell begins with the recognition of the ACE2 receptor. Then, the S1 subunit moves, modifying the protein's conformation in way that determinants for the virus-cell binding. Due to the conformational movements, the protein structure assumes a conformation which is suitable for binding with the ACE2 receptor. At that instance, the spike protein is found in a "up" conformation, hence the protein's name. | ||
