1bi9: Difference between revisions

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[[Image:1bi9.gif|left|200px]]
{{Seed}}
[[Image:1bi9.png|left|200px]]


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{{STRUCTURE_1bi9|  PDB=1bi9  |  SCENE=  }}  
{{STRUCTURE_1bi9|  PDB=1bi9  |  SCENE=  }}  


'''RETINAL DEHYDROGENASE TYPE TWO WITH NAD BOUND'''
===RETINAL DEHYDROGENASE TYPE TWO WITH NAD BOUND===




==Overview==
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Retinoic acid, a hormonally active form of vitamin A, is produced in vivo in a two step process: retinol is oxidized to retinal and retinal is oxidized to retinoic acid. Retinal dehydrogenase type II (RalDH2) catalyzes this last step in the production of retinoic acid in the early embryo, possibly producing this putative morphogen to initiate pattern formation. The enzyme is also found in the adult animal, where it is expressed in the testis, lung, and brain among other tissues. The crystal structure of retinal dehydrogenase type II cocrystallized with nicotinamide adenine dinucleotide (NAD) has been determined at 2.7 A resolution. The structure was solved by molecular replacement using the crystal structure of a mitochondrial aldehyde dehydrogenase (ALDH2) as a model. Unlike what has been described for the structures of two aldehyde dehydrogenases involved in the metabolism of acetaldehyde, the substrate access channel is not a preformed cavity into which acetaldehyde can readily diffuse. Retinal dehydrogenase appears to utilize a disordered loop in the substrate access channel to discriminate between retinaldehyde and short-chain aldehydes.
The line below this paragraph, {{ABSTRACT_PUBMED_10320326}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_10320326}}


==About this Structure==
==About this Structure==
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[[Category: Aldehyde dehydrogenase]]
[[Category: Aldehyde dehydrogenase]]
[[Category: Retinoid]]
[[Category: Retinoid]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:32:48 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:12:30 2008''

Revision as of 16:12, 30 June 2008

File:1bi9.png

Template:STRUCTURE 1bi9

RETINAL DEHYDROGENASE TYPE TWO WITH NAD BOUND

Template:ABSTRACT PUBMED 10320326

About this Structure

1BI9 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

The structure of retinal dehydrogenase type II at 2.7 A resolution: implications for retinal specificity., Lamb AL, Newcomer ME, Biochemistry. 1999 May 11;38(19):6003-11. PMID:10320326

Page seeded by OCA on Mon Jun 30 19:12:30 2008

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