1bii: Difference between revisions

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[[Image:1bii.gif|left|200px]]
{{Seed}}
[[Image:1bii.png|left|200px]]


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{{STRUCTURE_1bii|  PDB=1bii  |  SCENE=  }}  
{{STRUCTURE_1bii|  PDB=1bii  |  SCENE=  }}  


'''THE CRYSTAL STRUCTURE OF H-2DD MHC CLASS I IN COMPLEX WITH THE HIV-1 DERIVED PEPTIDE P18-110'''
===THE CRYSTAL STRUCTURE OF H-2DD MHC CLASS I IN COMPLEX WITH THE HIV-1 DERIVED PEPTIDE P18-110===




==Overview==
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The structure of H-2Dd complexed with the HIV-derived peptide P18-I10 (RGPGRAFVTI) has been determined by X-ray crystallography at 2.4 A resolution. This MHC class I molecule has an unusual binding motif with four anchor residues in the peptide (G2, P3, R/K/H5, and I/L/F9 or 10). The cleft architecture of H-2Dd includes a deep narrow passage accomodating the N-terminal part of the peptide, explaining the obligatory G2P3 anchor motif. Toward the C-terminal half of the peptide, p5R to p8V form a type I' reverse turn; residues p6A to p9T, and in particular p7F, are readily exposed. The structure is discussed in relation to functional data available for T cell and natural killer cell recognition of the H-2Dd molecule.
The line below this paragraph, {{ABSTRACT_PUBMED_9729040}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_9729040}}


==About this Structure==
==About this Structure==
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[[Category: Major histocompatibility complex class i dd]]
[[Category: Major histocompatibility complex class i dd]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:33:17 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:13:06 2008''

Revision as of 16:13, 30 June 2008

File:1bii.png

Template:STRUCTURE 1bii

THE CRYSTAL STRUCTURE OF H-2DD MHC CLASS I IN COMPLEX WITH THE HIV-1 DERIVED PEPTIDE P18-110

Template:ABSTRACT PUBMED 9729040

About this Structure

1BII is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4 A resolution: implications for T cell and NK cell recognition., Achour A, Persson K, Harris RA, Sundback J, Sentman CL, Lindqvist Y, Schneider G, Karre K, Immunity. 1998 Aug;9(2):199-208. PMID:9729040

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