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| [[Image:1bik.gif|left|200px]] | | {{Seed}} |
| | [[Image:1bik.png|left|200px]] |
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| {{STRUCTURE_1bik| PDB=1bik | SCENE= }} | | {{STRUCTURE_1bik| PDB=1bik | SCENE= }} |
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| '''X-RAY STRUCTURE OF BIKUNIN FROM THE HUMAN INTER-ALPHA-INHIBITOR COMPLEX'''
| | ===X-RAY STRUCTURE OF BIKUNIN FROM THE HUMAN INTER-ALPHA-INHIBITOR COMPLEX=== |
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| ==Overview==
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| Bikunin is a serine protease inhibitor found in the blood serum and urine of humans and other animals. Its sequence shows internal repetition, suggesting that it contains two domains that resemble bovine pancreatic trypsin inhibitor (BPTI). A fragment of bikunin has been crystallised, its structure solved and subsequently refined against 2.5 A data. The two BPTI-like domains pack closely together and are related by an approximate 60 degrees rotation combined with a translation. These domains are very similar to each other and other proteins with this fold. The largest variations occur in the loops responsible for protease recognition. The loops of the first domain are unobstructed by the remaining protein. However, the loops of the second domain are close to the first domain and it is possible that protease binding may be affected or, in some cases, abolished by the presence of the first domain. Thus, cleavage of the two domains could alter the substrate specificity of domain II. Bikunin has a hydrophobic patch close to the N terminus of domain I, which is the most likely site for cell-surface receptor binding. In addition, there is a basic patch at one end of domain II that may be responsible for the inhibition of calcium oxalate crystallization in urine.
| | The line below this paragraph, {{ABSTRACT_PUBMED_9566199}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 9566199 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_9566199}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Urinary trypsin inhibitor]] | | [[Category: Urinary trypsin inhibitor]] |
| [[Category: Uronic-acid-rich protein]] | | [[Category: Uronic-acid-rich protein]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:33:21 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:13:10 2008'' |
