7c44: Difference between revisions

Line 1:

==Crystal structure of the p53-binding domain of human MdmX protein in complex with Nutlin3a==

== Structural highlights ==

<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C44 OCA]. For a guided tour on the structure components use [~~http~~://proteopedia.org/fgij/fg.htm?mol=7C44 FirstGlance].

<table><tr><td colspan='2'>[[7c44]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C44 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=7C44 FirstGlance].

</td></tr><tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[~~http~~://proteopedia.org/fgij/fg.htm?mol=7c44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c44 OCA], [~~http~~://pdbe.org/7c44 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7c44 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7c44 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7c44 ProSAT]</td></tr>

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NUT:4-({(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-[4-METHOXY-2-(PROPAN-2-YLOXY)PHENYL]-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}CARBONYL)PIPERAZIN-2-ONE'>NUT</scene>, <scene name='pdbligand=O4B:1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE'>O4B</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=7c44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c44 OCA], [https://pdbe.org/7c44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c44 RCSB], [https://www.ebi.ac.uk/pdbsum/7c44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c44 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>

==See Also==

*[[MDM4|MDM4]]

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Cao CZ]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
 ==Crystal structure of the p53-binding domain of human MdmX protein in complex with Nutlin3a==
-<StructureSection load='7c44' size='340' side='right'caption='[[7c44]]' scene=''>
+<StructureSection load='7c44' size='340' side='right'caption='[[7c44]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C44 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7C44 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[7c44]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C44 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7c44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c44 OCA], [http://pdbe.org/7c44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7c44 RCSB], [http://www.ebi.ac.uk/pdbsum/7c44 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7c44 ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NUT:4-({(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-[4-METHOXY-2-(PROPAN-2-YLOXY)PHENYL]-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}CARBONYL)PIPERAZIN-2-ONE'>NUT</scene>, <scene name='pdbligand=O4B:1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE'>O4B</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c44 OCA], [https://pdbe.org/7c44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c44 RCSB], [https://www.ebi.ac.uk/pdbsum/7c44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c44 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>
+==See Also==
+*[[MDM4|MDM4]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
 [[Category: Cao CZ]]