1bau: Difference between revisions
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New page: left|200px<br /> <applet load="1bau" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bau" /> '''NMR STRUCTURE OF THE DIMER INITIATION COMPL... |
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[[Image:1bau.gif|left|200px]]<br /> | [[Image:1bau.gif|left|200px]]<br /><applet load="1bau" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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'''NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA, MINIMIZED AVERAGE STRUCTURE'''<br /> | '''NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA, MINIMIZED AVERAGE STRUCTURE'''<br /> | ||
==Overview== | ==Overview== | ||
Retroviral genomes must dimerize to be fully infectious. Dimerization is | Retroviral genomes must dimerize to be fully infectious. Dimerization is directed by a unique RNA hairpin structure with a palindrome in its loop: hairpins of two strands first associate transiently through their loops, and then refold to a more stable, linear duplex. The structure of the initial, kissing-loop dimer from HIV-1, solved using 2D NMR, is bent and metastable, its interface being formed not only by standard basepairing between palindromes, but also by a distinctive pattern of interstrand stacking among bases at the stem-loop junctions. This creates mechanical distortions that partially melt both stems, which may facilitate spontaneous refolding of this RNA complex into linear form. | ||
==About this Structure== | ==About this Structure== | ||
1BAU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http:// | 1BAU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAU OCA]. | ||
==Reference== | ==Reference== | ||
Structure of the dimer initiation complex of HIV-1 genomic RNA., Mujeeb A, Clever JL, Billeci TM, James TL, Parslow TG, Nat Struct Biol. 1998 Jun;5(6):432-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9628479 9628479] | Structure of the dimer initiation complex of HIV-1 genomic RNA., Mujeeb A, Clever JL, Billeci TM, James TL, Parslow TG, Nat Struct Biol. 1998 Jun;5(6):432-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9628479 9628479] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Billeci, T | [[Category: Billeci, T M.]] | ||
[[Category: Clever, J | [[Category: Clever, J L.]] | ||
[[Category: James, T | [[Category: James, T L.]] | ||
[[Category: Mujeeb, A.]] | [[Category: Mujeeb, A.]] | ||
[[Category: Parslow, T | [[Category: Parslow, T G.]] | ||
[[Category: dimerization]] | [[Category: dimerization]] | ||
[[Category: encapsidation]] | [[Category: encapsidation]] | ||
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[[Category: rna]] | [[Category: rna]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:53:18 2008'' | ||
